Abstract

Many population-based studies consistently demonstrate some significant correlation between plasma levels of TG, LDL cholesterol, HDL cholesterol, different inflammatory cytokines and the prevalence of coronary heart disease (CHD). This article aimed to analyze the correlation between the occurrences of CHD with profile of lipid and cytokines. This is a meta-analysis study evaluating all pubmed, web of sciences, science direct, Scopus and Google scholar articles about the CHD and lipid and/or cytokine profiles from 2010 to 2012 using analytical statistical nalysis. Data were collected and the related information extracted and put in statistical package and analyzed. According to the analysis of many studies healthy individuals have higher levels of HDL lipoprotein than those with CHD so that An estimated of 1 mg/dl higher HDL-C is associated with a 2 lower risk of CHD for men and a 3 lower for the women. The plasma levels of Interleukin-6, CRP, TNF alpha, IL-18, IL-15, complement C3, colony stimulating factor (M-CSF), ICAM-1, CD54) on CD14+ CD16+ all are increased among CHD patients and therefore considered as risk markers of MI-coronary death. Profiles of lipid and cytokines are good predictors for CHD particularly if they to be evaluated and analyzed simultaneously and management of both groups can change the severity of the disease. Havasian MR, Panahi J, Khosravi A. Correlation between the lipid and cytokine profiles in patients with coronary heart disease (CHD)-(Review article). Life Sci J 2012;9(4):5772-5777 (ISSN:1097-8135). http://www.lifesciencesite.com. 859