Abstract

Background: A probiotic is a living microorganism that promotes host health when grown under appropriate con-ditions. Kidney stones are one of the universal agonizing diseases that have increased dramatically in recent years. One of the causes of this disease is hyperoxaluria (HOU), which is known to be an important factor in the forma-tion of oxalate stones and is manifested by high levels of oxalate in the urine. In addition, about 80 of kidney stones contain oxalate, and decomposition of this material by microbes is one way to dispose of it.Methods: Therefore, we examined a bacterial mixture containing Lactobacillus plantarum, Lactobacillus casei, Lac-tobacillus acidophilus, and Bifidobacterium longum to prevent of oxalate production in Wistar rats with kidney stones. We divided the rats into 6 groups defined in the method.Results: The results of this study clearly show a decrease in urinary oxalate levels by exogenous means by L. plan-tarum, L. casei, L. acidophilus, and B. longum at the beginning of the experiment. Therefore, these bacteria can be used to control and prevent the formation of kidney stones.Conclusions: However, further studies should be conducted on the effects of these bacteria, and it is recommended to identify the gene responsible for the degradation of oxalate in order to develop a new probiotic.