Abstract

Background: Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus (DM) and is identified as a leading cause of the end-stage renal disease (ESRD). Considering the importance of early prediction of individuals at risk of this complication, the use of intelligent models through machine learning (ML) algorithms can be helpful. Therefore, this study aimed to identify the influential variables in predicting DN and fed them as inputs to develop an ML-based decision support system (DSS) for DN diagnosis. Methods: The data of 327 patients with diabetes (types 1 and 2) were retrospectively analyzed. After data preparation, the genetic algorithm (GA) feature selection method was used to identify the predictor variables affecting DN. Then, several ML algorithms, including the support vector machine (SVM), decision tree (DT), K-nearest neighbors (KNN), and artificial neural networks (ANN) were used to train predictive models based on the selected features. Afterward, the performance of the developed models was evaluated using sensitivity, specificity, and accuracy criteria in 10 independent runs. Finally, the DSS was developed based on the best fit model in the C# programming language. Results: Our findings illustrated that age, hemoglobin A1c (HbA1c) test, diastolic arterial pressure (DAP), systolic arterial pressure (SAP), fasting glycemia rate (FGR), and DM involvement time were the most important factors in predicting DN. Moreover, to predict the DN, GA combined with the DT algorithm obtained the highest performance in terms of accuracy, sensitivity, specificity, and area under the curve (AUC), equal to 98.9, 98.6, 99.2, and 98.9, respectively. Conclusions: The results revealed that GA combined with the DT classifier predicted DN with significant accuracy. Thus, the DSS developed based on DT can be considered a reliable tool to help physicians make decisions. Future studies are warranted to further validate the applicability of our model in clinical settings. © 2022