Abstract

The common disadvantages of BCG vaccine is topical lymphadenitis, this patient must be treatment by anti-tuberculosis drugs. Systematic form of lymphadenitis has high mortality. This study aimed to evaluate anti tuberculosis drugs sensitivity of BCG pasture strain isolated from children with lymphadenitis after BCG vaccination to compare with BCG pasture strain. The samples from children with lymphadenitis were collected and cultured on glycerol free-middle brook 7h11 and lowenstien Jensen. The positive culture was confirmed by real time PCR and MIC of Ethionamide, Rifampicin and. For BCG pasture strain vaccination and isolation from adults was determined. In the all samples the 30 cases (37.5) had positive culture, in 2 cases of which, because of patient`s underlying immunodeficiency, the co-bacterial infection was observed. The MIC of Isoniazid, Rifampicin, Streptomycin, Ethambutol, Clarithromycin, Amikacin and Ethionamide in pasture strain of BCG vaccine and adenitis almost were similar. In order to similarity of anti-tuberculosis drugs, sensitivity of vaccine strain and adenitis in systemic cases, the first line drug could use.