Abstract

Introduction: Polycystic ovary syndrome (PCOS) is an endocrinopathy with unknown pathophysiology among women of reproductive age. Several studies have been conducted to determine the prevalence of metabolic syndrome (MetS) among PCOS patients. However, the results were contradictory. The present study was conducted to evaluate the prevalence of MetS in PCOS patients using the related published data. Method: The present systematic review was perfumed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search was done using MeSH keywords in databases of PubMed, Scopus, Embase, CINAHL, Web of Science, Cochrane Library, EBSCO, and Google scholar search engine as well as the reference list of the retrieved papers without time limit until October 2018. We used Cochran's Q test and I-2 Index to evaluate the heterogeneity among the studies and the random effects model was used to combine the results. Data analysis was performed using Stata ver. 11.1. Results: Forty six studies including 8946 patients with PCOS were included in the final analysis. Total heterogeneity was high (I-2 : 91.43, P <0.001). The prevalence of MetS in PCOS patients was estimated to be 30 (95CI: 27-33). Subgroup analysis based on MetS diagnostic criteria showed an estimated prevalence of 0.27 (95CI: 0.18-0.37), 0.30 (95Cl: 0.27-0.34), 0.32 (95CI: 0.25-0.39), 0.32 (95CI: 0.27-0.37) and 0.24 (95CI: 0.14-0.34) for IDF, NECP-ATPIII, AHA NHLBI, CDS, and unknown criteria, respectively. Conclusion: Considering the prevalence of MetS in PCOS patients, diagnosis of MetS in PCOS patients is necessary to reduce the mortality and morbidity rates. (C) 2019 Published by Elsevier Ltd on behalf of Diabetes India.