Abstract

Autologous cells in cell therapy is useful in accelerating the Curing course of lesions through reducing time required for early synthesis of new derm by the host cells to invade the lesion tissue. Collagen and hyaluronic acid matrices are also effective in accelerating the lesion curing process. They increase migration of host cells and blood vessels into the tissue and allow rapid replacement by host tissue. The cell-scaffold complex is grafted onto the defect area and covered with a polyurethane foam dressing. Practical challenges including scale up, formulation, storage, transport and delivery mechanisms are the main challenges to development and clinical translation of preclinical observations. However, recent FDA consent of fibroblast treatment applications for nasolabial folds and the expanding pipeline of other fibroblast therapies in clinical development show that cellular therapy is an expanding field.