Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Biosynthesis of zinc nanoparticles using Allium saralicum RM Fritsch leaf extract; Chemical characterization and analysis of their cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing properties

Wed Nov 30 07:25:41 2022

(2020) Biosynthesis of zinc nanoparticles using Allium saralicum RM Fritsch leaf extract; Chemical characterization and analysis of their cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing properties. Applied Organometallic Chemistry. p. 18. ISSN 0268-2605

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Abstract

The extract of Allium saralicum R.M. Fritsch leaf was found to be an effective reagent for green synthesis and functionalization of zinc nanoparticles (ZnNPs@AS) from 1 mM zinc acetate solution. These nanoparticles were characterized by fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), field emission scanning electron microscopy (FE-SEM), and transmission electron microscopy (TEM) analysis. FT-IR results offered polysaccharides and protein in A. saralicum were the sources of reducing power, reducing zinc ions to ZnNPs@AS. In XRD analysis, the crystal size of zinc nanoparticles was 19.7 nm. TEM and FE-SEM images indicated the average diameter of 19 nm for the zinc nanoparticles. For investigating the antimicrobial properties of Zn (NO3)(2).6H(2)O, A. saralicum, and ZnNPs@AS, we used the macro-broth dilation test. Also, MIC, MBC, and MFC of Zn (NO3)(2).6H(2)O, A. saralicum, and ZnNPs@AS were gained to indicate the exact antimicrobial potentials of them. ZnNPs@AS indicated higher antifungal and antibacterial effects than all standard antibiotics (p <= 0.01). The MIC of ZnNPs@AS were 2-4 and 2-8 mg/mL against fungi and bacteria, respectively. But, MBC and MFC of ZnNPs@AS were 4-8 mg/mL against all fungi and bacteria tested. To survey the cutaneous wound healing effects of Zn (NO3)(2).6H(2)O, A. saralicum, and ZnNPs@AS, the 0.2 ointments were formulated and compared with the control and untreated groups. The use of ZnNPs@AS ointment significantly (p <= 0.01) raised the wound contracture, vessel, hydroxyl proline, hexuronic acid, hexosamine, fibrocyte, fibroblast, and fibrocytes/fibroblast rate and significantly (p <= 0.01) decreased the wound area, total cells, neutrophil, macrophage, and lymphocyte compared to other groups in rats. According to the above findings, ZnNPs@AS may be consumed for the treatment of cutaneous wounds and infectious diseases in humans.

Item Type: Article
Creators:
CreatorsEmail
Zhang, C. N.UNSPECIFIED
Liu, J. Y.UNSPECIFIED
Ahmeda, A.UNSPECIFIED
Liu, Y. D.UNSPECIFIED
Feng, J. Y.UNSPECIFIED
Guan, H.UNSPECIFIED
Li, C. Y.UNSPECIFIED
Nowrozi, M.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Almasi, M.UNSPECIFIED
Keywords: Allium saralicum R M Fritsch biosynthesis therapeutic activities zinc nanoparticles ethanolic extract hydrogen-peroxide activation acid Chemistry
Divisions:
Page Range: p. 18
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Identification Number: https://doi.org/10.1002/aoc.5564
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2623

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