Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran

Tue Dec 6 05:13:38 2022

(2018) Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran. Recent patents on anti-infective drug discovery. pp. 180-186. ISSN 2212-4071 (Electronic) 1574-891X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29769010

Abstract

BACKGROUND: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran. METHOD: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Antibiotic sensitivity and Extended Spectrum Beta Lactamase (ESBL) production were tested using agar dilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. ESBL genes (blaTEM, bla SHV,bla CTX-M), plasmid-encoded fosfomycin resistance genes (fosA, fosB, fosA3 and fosC2) and chromosomal mutations (murA, glpT, uhpT) were detected by Polymerase Chain Reaction (PCR). RESULTS: In this study, 151 of the 355 isolates were ESBL-positive. blaCTX-M (77) was the most common gene followed by blaSHV (70) and blaTEM (58), either alone or in combination. Eighty nine percent (132/151) of the ESBL-positive isolates were MDR. Antimicrobial susceptibility rates were higher for fosfomycin (92.8) and imipenem (35.5) among ESBL-positive isolates. None of the ESBL- positive isolates harbored any mutations or plasmid-mediated fosfomycin resistance determinants. CONCLUSION: In conclusion, fosfomycin showed good antimicrobial activity against multidrug resistance ESBL- positive Enterobacteriaceae.

Item Type: Article
Creators:
CreatorsEmail
Ghanavati, R.UNSPECIFIED
Ohadi, E.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Yazdani, F.UNSPECIFIED
Torki, A.UNSPECIFIED
Kalani, B. S.UNSPECIFIED
Irajian, G.UNSPECIFIED
Keywords: Esbl ESBL- positive Enterobacteriaceae Fosfomycin fos gene infections phosphonic acid.
Divisions:
Page Range: pp. 180-186
Journal or Publication Title: Recent patents on anti-infective drug discovery
Journal Index: Pubmed
Volume: 13
Number: 2
Identification Number: https://doi.org/10.2174/1574891X13666180517075803
ISSN: 2212-4071 (Electronic) 1574-891X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/983

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