Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The association between Selenium and Prostate Cancer: a Systematic Review and Meta-Analysis

Fri Apr 12 18:29:08 2024

(2018) The association between Selenium and Prostate Cancer: a Systematic Review and Meta-Analysis. Asian Pacific journal of cancer prevention : APJCP. pp. 1431-1437. ISSN 2476-762X (Electronic) 1513-7368 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29936712

Abstract

Background: Evidence of relationship between selenium and prostate cancer has been inconsistent. The present metaanalysis was conducted to determine relationship between selenium and prostate cancer. Methods: A systematic review and meta-analysis was carried out using preferred reporting items for systematic reviews and meta-analysis (PRISMA). We searched PubMed, Scopus, Web of Science, ScienceDirect, Embase, CINAHL, Cochrane Library, EBSCO and Google scholar search engines and the reference lists of the retrieved papers for relevant data, without any limitation regarding language or time until 2016. Heterogeneity among studies was evaluated using Q test and I2 Index. Finally, a random effects model was used for combining results using STATA software version 11.1. P<0.05 was considered significant. Results: Thirty-eight studies including 36,419 cases and 105,293 controls were included in the final analysis. The pooled relative risk (RR) of relation between selenium and prostate cancer was 0.86 (95 Confidence Interval CI:0.78-0.94). Sub-group analyses based on case-control, cohort, and RCT studies gave values of 0.89 (95% CI: 0.80-1.00), 0.77 (95% CI: 0.52-1.14) and 0.90 (95% CI: 0.74-1.09), respectively. RRs based on serum, plasma and nail samples were 0.69 (95% CI: 0.51-0.95), 0.85 (95% CI: 0.61-1.17), 0.66 (95% CI: 0.41-1.05), respectively. According to 10 studies, investigated the relation between advanced prostate cancer and selenium in which the RR was 0.67 (95% CI: 0.52-0.87). Conclusions: This meta-analysis indicated that selenium most probably has a protective role against development of prostate cancer and its progression to advanced stages. Therefore, selenium supplementation can be proposed for prevention of prostate cancer.

Item Type: Article
Creators:
CreatorsEmail
Sayehmiri, K.UNSPECIFIED
Azami, M.UNSPECIFIED
Mohammadi, Y.UNSPECIFIED
Soleymani, A.UNSPECIFIED
Tardeh, Z.UNSPECIFIED
Keywords: Antioxidants/*therapeutic use Case-Control Studies Humans Male Prognosis Prostatic Neoplasms/*prevention & control Selenium/*therapeutic use *Selenium *prostate cancer *meta-analysis
Divisions:
Page Range: pp. 1431-1437
Journal or Publication Title: Asian Pacific journal of cancer prevention : APJCP
Journal Index: Pubmed
Volume: 19
Number: 6
Identification Number: https://doi.org/10.22034/APJCP.2018.19.6.1431
ISSN: 2476-762X (Electronic) 1513-7368 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/976

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