Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In vitro anti-mycobacterial activity of three medicinal plants of Lamiaceae family

Wed Nov 30 06:52:22 2022

(2018) In vitro anti-mycobacterial activity of three medicinal plants of Lamiaceae family. Recent patents on anti-infective drug discovery. ISSN 2212-4071 (Electronic) 1574-891X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29952265

Abstract

BACKGROUND: Mycobacterium tuberculosis as an intracellular pathogen causes tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Among them, Lamiaceae family are of pharmaceutical interest because of their potential antimicrobial properties. The aim of the study was to evaluate the in vitro activities of Satureja rechingeri, Satureja khuzestanica and Zataria multiflora against MDR M. tuberculosis and two non-tuberculous mycobacteria (NTM). The recent patents on plant compositions (US7641919 B2, US7887860 B2, US 8865231 B2, US 9345659 B2, WO 2014158797 A1 and WO 2014158877 A1) helped in selecting the anti-mycobacterial drugs. METHODS: The essential oils were prepared by the standard method. The confirmed strains were obtained from the microbial collection of Tehran University of Medical Sciences. Minimum inhibitory concentrations (MICs) of essential oils of plants against mycobacterial strains were determined using standard broth microdilution method. RESULTS: MDR M. tuberculosis was completely inhibited by Z. multiflora at 78mug/ml concentration. S. rechingeri and S. khuzestanica also showed same anti-mycobacterial activity against MDR M. tuberculosis with MICs of 156 mug/ml. The MICs of the essential oils against M. tuberculosis H37Rv, M. kansasii and M. fortuitum were in the range from 39 to 156 mug/ml. CONCLUSION: The studied medicinal plants showed notable effects against mycobacterial strains. Our results indicated that utilization of Lamiaceae family can be helpful for treatment of mycobacterial infections.

Item Type: Article
Creators:
CreatorsEmail
Kazemian, H.UNSPECIFIED
Heidari, H.UNSPECIFIED
Yamchi, J. K.UNSPECIFIED
Zandi, H.UNSPECIFIED
Taji, A.UNSPECIFIED
Yazdani, F.UNSPECIFIED
Ghanavati, R.UNSPECIFIED
Rahdar, H. A.UNSPECIFIED
Feizabadi, M. M.UNSPECIFIED
Keywords: Anti-mycobacterial Essential oil Satureja khuzestanica Satureja rechingeri Zataria multiflora
Divisions:
Journal or Publication Title: Recent patents on anti-infective drug discovery
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1574891X13666180626170155
ISSN: 2212-4071 (Electronic) 1574-891X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/974

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