Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis

Wed Jun 29 10:43:55 2022

(2018) Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis. Archives of endocrinology and metabolism. pp. 438-445. ISSN 2359-4292 (Electronic) 2359-3997 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30304108

Abstract

OBJECTIVE: This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. SUBJECTS AND METHODS: In a randomized, double-blind trial study, 60 postmenopausal women were divided into three groups: control, alendronate, and alendronate + curcumin. Each group included 20 patients. Total body, total hip, lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after 12 months of therapy. Bone turnover markers such as bone-specific alkaline phosphatase (BALP), osteocalcin and C-terminal cross-linking telopeptide of type I collagen (CTx) were measured at the outset and 6 months later. RESULTS: Patients in the control group suffered a significant decrease in BMD and increased bone turnover markers at the end of study. The group treated with only alendronate showed significantly decreased levels of BALP and CTx and increased levels of osteocalcin compared to the control group. The alendronate group also showed significant increases in the total body, total hip, lumbar spine and femoral neck BMDs at the end of study compared to the control group. In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups. BMD indexes also increased in four areas significantly at the end of study compared to the control and alendronate groups. CONCLUSION: The combination of curcumin and alendronate has beneficial effects on BMD and bone turnover markers among postmenopausal women with osteoporosis. Arch Endocrinol Metab. 2018;62(4):438-45.

Item Type: Article
Creators:
CreatorsEmail
Khanizadeh, F.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Keywords: Aged Alendronate/*pharmacology Alkaline Phosphatase/analysis/drug effects Bone Density/*drug effects Bone Density Conservation Agents/*pharmacology Bone Remodeling/drug effects Collagen Type II/drug effects/urine Curcumin/*pharmacology Double-Blind Method Drug Therapy, Combination/methods Female Humans Middle Aged Osteocalcin/analysis/drug effects Osteoporosis, Postmenopausal/*metabolism Peptide Fragments/drug effects/urine
Divisions:
Page Range: pp. 438-445
Journal or Publication Title: Archives of endocrinology and metabolism
Journal Index: Pubmed
Volume: 62
Number: 4
Identification Number: https://doi.org/10.20945/2359-3997000000060
ISSN: 2359-4292 (Electronic) 2359-3997 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/948

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