Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer

Thu Oct 6 08:39:07 2022

(2018) The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer. Journal of Cellular Physiology. ISSN 1097-4652 (Electronic) 0021-9541 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30417346

Abstract

RNA helicase p68 or DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5) is a unique member of the highly conserved protein family, which is involved in a broad spectrum of biological processes, including transcription, translation, precursor messenger RNA processing or alternative splicing, and microRNA (miRNA) processing. It has been shown that p68 is necessary for cell growth and participates in the early development and maturation of some organs. Interestingly, p68 is a transcriptional coactivator of numerous oncogenic transcription factors, including nuclear factor-kappabeta (NF-kappabeta), estrogen receptor alpha (ERalpha), beta-catenin, androgen receptor, Notch transcriptional activation complex, p53 and signal transducer, and activator of transcription 3 (STAT3). Recent studies on the role of p68 (DDX5) in multiple dysregulated cellular processes in various cancers and its abnormal expression indicate the importance of this factor in tumor development. Discussion of the precise role of p68 in cancer is complex and depends on the cellular microenvironment and interacting factors. In terms of the deregulated expression of p68 in breast cancer and the high prevalence of this cancer among women, it can be informative to review the precise function of this factor in the breast cancer. Therefore, an attempt will be made in this review to clarify the tumorigenic function of p68 in association with its targeting potential for the treatment of breast cancer.

Item Type: Article
Creators:
CreatorsEmail
Hashemi, V.UNSPECIFIED
Masjedi, A.UNSPECIFIED
Hazhir-Karzar, B.UNSPECIFIED
Tanomand, A.UNSPECIFIED
Shotorbani, S. S.UNSPECIFIED
Hojjat-Farsangi, M.UNSPECIFIED
Ghalamfarsa, G.UNSPECIFIED
Azizi, G.UNSPECIFIED
Anvari, E.UNSPECIFIED
Baradaran, B.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: Ddx5 RNA helicase breast cancer p68
Divisions:
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: Pubmed
Identification Number: https://doi.org/10.1002/jcp.26912
ISSN: 1097-4652 (Electronic) 0021-9541 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/940

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