Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

C/EBP homologous protein investigation in the serum and cerebro-spinal fluid of relapsing-remitting multiple sclerosis patients

(2019) C/EBP homologous protein investigation in the serum and cerebro-spinal fluid of relapsing-remitting multiple sclerosis patients. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. pp. 51-54. ISSN 1532-2653 (Electronic) 0967-5868 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30446370

Abstract

The exact determination of endoplasmic reticulum (ER) stress-associated proteins is not completely elucidated in the multiple sclerosis (MS) patients. We measured CHOP concentrations in the serum and cerebro-spinal fluid (CSF) of relapsing-remitting MS (RRMS) patients (n=20) in comparison with the non-MS control group (n=20) to determine whether this marker could be detected in the body fluids of RRMS patients. CHOP marker was not detectable in all harvested CSF samples. However, its levels were detectable in all serums harvested from both non-MS and RRMS patients and its levels in the latter group were not significantly higher than those of the non-MS control group (P value=0.265). CHOP was not detectable in the CSF of RRMS patients in spite of the recent reports on the RRMS autopsies. Additionally, there were not any significant correlations (Spearman's correlation) between both of EDSS score and age with CHOP serum concentrations in all subjects.

Item Type: Article
Keywords: Chop Endoplasmic reticulum stress Relapsing remitting multiple sclerosis Unfolded protein response
Page Range: pp. 51-54
Journal or Publication Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Journal Index: Pubmed
Volume: 59
Identification Number: https://doi.org/10.1016/j.jocn.2018.11.008
ISSN: 1532-2653 (Electronic) 0967-5868 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/936

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