Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Hypolipidemic activity of Anethum graveolens in rats

Sun Apr 14 10:22:53 2024

(2008) Hypolipidemic activity of Anethum graveolens in rats. Phytotherapy Research. pp. 372-375. ISSN 0951-418X

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Abstract

The aerial parts of Anethum graveolens (dillweed) are used in Iran as a hypolipidemic agent. The scientific basis for its use has yet to be established. In this study the hypolipidemic activity of dill powder and its essential oil (its most important fraction) were evaluated in male Wistar rats (180 +/- 20 g) fed a high cholesterol diet. Anethum graveolens essential oil (AGEO) was prepared by hydrodistillation and analysed using GUMS. AGEO had a yield of 2 and GUMS analysis showed that alpha-phellandrene (32), limonene (28) and carvone (28) were its major components. Daily oral administration of AGEO to rats at doses of 45, 90 and 180 mg/kg for 2 weeks significantly and in a dose-dependent manner reduced total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C). AGEO also increased significantly high density lipoprotein cholesterol (HDL-C). Anethum graveolens powder when added to the diet of animals showed similar effects on serum lipids. It is concluded that Anethum graveolens has significant lipid lowering effects and is a promising cardioprotective agent. Copyright (C) 2007 John Wiley & Sons, Ltd.

Item Type: Article
Creators:
CreatorsEmail
Hajhashemi, V.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Keywords: anethum graveolens essential oil hypolipidemic activity low-density-lipoprotein coronary heart-disease cholesterol serum mevinolin plasma Pharmacology & Pharmacy
Divisions:
Page Range: pp. 372-375
Journal or Publication Title: Phytotherapy Research
Journal Index: ISI
Volume: 22
Number: 3
Identification Number: https://doi.org/10.1002/ptr.2329
ISSN: 0951-418X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/911

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