Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Salivary cotinine, doctor-diagnosed asthma and respiratory symptoms in primary schoolchildren

Wed Jun 19 08:16:48 2024

(2008) Salivary cotinine, doctor-diagnosed asthma and respiratory symptoms in primary schoolchildren. Maternal and Child Health Journal. pp. 188-193. ISSN 1092-7875

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Due to impaired airway function, children are at risk for adverse respiratory symptoms if exposed to environmental tobacco smoke (ETS). A community-based, cross-sectional study of 425 children (5-11 years) attending 15 primary schools in a low socio-economic area of Merseyside/UK was undertaken to investigate the association of adverse respiratory symptoms and ETS exposure using a parent-completed questionnaire and children's salivary cotinine measurements. Overall, 28.9 of children had doctor-diagnosed asthma (DDA) and 11.3 a history of hospital admission for respiratory illnesses. The symptom triad of cough, wheeze and breathlessness (C+W+B+) occurred in 12.6 of children. The geometric mean cotinine level was 0.37 ng/ml (95 CI, 0.33-0.42 ng/ml) and it was estimated that 45.6 of children were ETS exposed. A history of asthma in the family was reported for 9.2 of fathers and 7.2 of mothers. Salivary cotinine level was significantly increased in children with DDA compared to those without (P = 0.002). Cotinine-validated levels adjusted odds ratio (AOR), 1.8; 95% CI, 1.4-2.5), low socio-economic (disadvantaged) status (AOR, 1.4; 1.1-2.9), child's male gender (AOR, 1.6; 1.1-2.5) and maternal smoking (AOR, 2.2; 1.4-3.1) were significantly associated with DDA. The cotinine-validated level (AOR, 1.4; 1.1-2.9) as well as maternal smoking (AOR, 1.8; 1.1-2.5), were also independently associated with C+W+B+. The use of salivary cotinine as an indicator of ETS exposure could be used to inform parents of exposure risk to their asthmatic children and may help re-enforce deterrent efforts to reduce childhood parental smoking exposure.

Item Type: Article
Keywords: asthma children cotinine respiratory symptoms environmental tobacco-smoke primary-school children birth cohort exposure risk merseyside prevalence childhood adolescence association Public, Environmental & Occupational Health
Page Range: pp. 188-193
Journal or Publication Title: Maternal and Child Health Journal
Journal Index: ISI
Volume: 12
Number: 2
Identification Number:
ISSN: 1092-7875
Depositing User: مهندس مهدی شریفی

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