Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antimicrobial susceptibility patterns and distribution of bla(OXA) genes among Acinetobacter spp. isolated from patients at Tehran hospitals

Tue Jun 25 02:18:20 2024

(2008) Antimicrobial susceptibility patterns and distribution of bla(OXA) genes among Acinetobacter spp. isolated from patients at Tehran hospitals. Japanese Journal of Infectious Diseases. pp. 274-278. ISSN 1344-6304

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Multiple drug-resistant strains of Acinetobacter have created therapeutic problems worldwide. This study was conducted to determine the antimicrobial susceptibility patterns and prevalence of bla(OXA-type) carbapenemases among isolates of Acinetobacter spp. obtained from Iranian patients. Here, 128 Acinetobacter isolates were identified at the species level, and their susceptibilities to different antibiotics were determined using disk agar diffusion testing. Isolates were then subjected to multiplex-PCR targeting bla(OXA) genes. More than 50 of the isolates showed multidrug resistance to different antibiotics. The rates of susceptibility to imipenem, meropenem, piperacillin-tazobactam, and amikacin were 50.7, 50, 42.1, and 38.2, respectively. The MICs of carbapenems for the resistant isolates ranged from 64 to >256 mu g/ml. All strains of Acinetobacter baumannii possessed a bla(OXA-51-like) gene. The co-existence of bla(OXA-51-like)/bla(OXA-23-like) and bla(OXA-51-like)/bla(OXA-24-like) was detected in 25 (n = 32) and 17.9 (n = 23) of the isolates, respectively. Over 70 of carbapenem-resistant strains contained at least two genes encoding OXA-type carbapenemase. Resistance to carbapenems in the population of Acinetobacter strains in Iran is high, with the majority of isolates showing multidrug resistance. A wide diversity of OXA genes exists among the strains of A. baumannii in Iran. Detection of bla(OXA-51-like) can be used as a simple and reliable method to differentiate A. baumannii strains from other species.

Item Type: Article
Fathollahzadeh, B.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Rasoolinejad, M.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Mohammadi-Yegane, S.UNSPECIFIED
Keywords: carbapenem-resistant acinetobacter hydrolyzing oxacillinase oxa-58 nosocomial outbreak beta-lactamases baumannii emergence enzyme europe Infectious Diseases
Page Range: pp. 274-278
Journal or Publication Title: Japanese Journal of Infectious Diseases
Journal Index: ISI
Volume: 61
Number: 4
ISSN: 1344-6304
Depositing User: مهندس مهدی شریفی

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