Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Distribution of different carbapenem resistant clones of Acinetobacter baumannii in Tehran Hospitals

Tue Apr 16 15:11:11 2024

(2009) Distribution of different carbapenem resistant clones of Acinetobacter baumannii in Tehran Hospitals. New Microbiologica. pp. 265-271. ISSN 1121-7138

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Abstract

The MICs of imipenem, meropenem, piperacillin-tazobactam, cefotaxime, polymixin B and tigecycline against 80 isolates of Acintobacter baumanii from 6 hospitals were determined. A multiplex-PCR was used to detect the genes encoding carbapenemases. Field Inversion Gel Electrophoresis (FIGE) was then used to investigate the genetic relationships among the carbapenem-resistant isolates. Only 7 isolates were resistant to polymixin B and tigecycline (MIC=16). All isolates were positive for at least 2 carbapenemase genes. At least 10 distinct clones were detected by FIGE. A dominant pattern designated as pulsotype A consisting of 23 isolates was detected from 4 hospitals. The majority of isolates in this pulsotype had a bla(OXA-51/23-like) and bla(OXA-51/24-like) carbapenemase genes and cultured from the patients at burns and ICU. The pan drug resistant isolates belonged to different FIGE patterns. Nosocomial infections with different clones of Acintobacter baumanii occur at Tehran hospitals. However, inter-hospital transmission with certain pulsotypes is likely

Item Type: Article
Creators:
CreatorsEmail
Morovat, T.UNSPECIFIED
Bahram, F.UNSPECIFIED
Mohammad, E.UNSPECIFIED
Setareh, S.UNSPECIFIED
Mehdi, F. M.UNSPECIFIED
Keywords: A. baumannii Carbapenem resistant FIGE patterns hydrolyzing oxacillinase oxa-58 intensive-care unit multiresistant acinetobacter nosocomial outbreak genes calcoaceticus tigecycline emergence prevalent imipenem Microbiology
Divisions:
Page Range: pp. 265-271
Journal or Publication Title: New Microbiologica
Journal Index: ISI
Volume: 32
Number: 3
ISSN: 1121-7138
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/888

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