Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Profound Alterations in the Intrinsic Excitability of Cerebellar Purkinje Neurons Following Neurotoxin 3-Acetylpyridine (3-AP)-Induced Ataxia in Rat: New Insights Into the Role of Small Conductance K+ Channels

Sat Jun 25 08:42:12 2022

(2011) Profound Alterations in the Intrinsic Excitability of Cerebellar Purkinje Neurons Following Neurotoxin 3-Acetylpyridine (3-AP)-Induced Ataxia in Rat: New Insights Into the Role of Small Conductance K+ Channels. Physiological Research. pp. 355-365. ISSN 0862-8408

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Abstract

Alterations in the intrinsic properties of Purkinje cells (PCs) may contribute to the abnormal motor performance observed in ataxic rats. To investigate whether such changes in the intrinsic neuronal excitability could be attributed to the role of Ca2+-activated K+ channels (K-Ca), whole cell current clamp recordings were made from PCs in cerebellar slices of control and ataxic rats. 3-AP induced profound alterations in the intrinsic properties of PCs, as evidenced by a significant increase in both the membrane input resistance and the initial discharge frequency, along with the disruption of the firing regularity. In control PCs, the blockade of small conductance K-Ca channels by UCL1684 resulted in a significant increase in the membrane input resistance, action potential (AP) half-width, time to peak of the AP and initial discharge frequency. SK channel blockade also significantly decreased the neuronal discharge regularity, the peak amplitude of the AP, the amplitude of the after-hyperpolarization and the spike frequency adaptation ratio. In contrast, in ataxic rats, both the firing regularity and the initial firing frequency were significantly increased by the blockade of SK channels. In conclusion, ataxia may arise from alterations in the functional contribution of SK channels, to the intrinsic properties of PCs.

Item Type: Article
Creators:
CreatorsEmail
Kaffashian, M.UNSPECIFIED
Shabani, M.UNSPECIFIED
Goudarzi, I.UNSPECIFIED
Behzadi, G.UNSPECIFIED
Zali, A.UNSPECIFIED
Janahmadi, M.UNSPECIFIED
Keywords: Cerebellar ataxia Intrinsic excitability Neurotoxin 3-acetylpyridine Purkinje neurons Small conductance Ca2+-activated K+ channels activated potassium channels spike frequency adaptation ca2+ channels in-vitro hippocampal-neurons pyramidal neurons calcium-channels dopamine neurons inferior olive sk channels Physiology
Divisions:
Page Range: pp. 355-365
Journal or Publication Title: Physiological Research
Journal Index: ISI
Volume: 60
Number: 2
ISSN: 0862-8408
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/858

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