Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Dynamics of the bacterially expressed conserved immunogenic region of the human respiratory syncytial virus G protein

Thu Jun 30 12:48:05 2022

(2011) Dynamics of the bacterially expressed conserved immunogenic region of the human respiratory syncytial virus G protein. Biotechnology and Applied Biochemistry. pp. 97-102. ISSN 0885-4513

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Abstract

Despite all efforts, there is still no effective vaccine available against the human respiratory syncytial virus (HRSV) that is a major cause of severe lower respiratory tract disease in infants and the elderly. In this review, we examined the potential of the conserved immunogenic region (residues 122-226) of the HRSV glycoprotein G alone as the inducer of neutralizing antibodies against this virus. The Escherichia coli produced recombinant conserved region of G (designated as G domain), which was used for rabbit immunization. Although rabbit is semipermissive host for HRSV, our result showed that the polyclonal antibodies against the G domain protein could strongly neutralize the virus (69.3), suggesting that the G immunogenic region of HRSV alone has a great potential in vaccine development. To our knowledge, this is the first report in which neutralizing antibodies to respiratory syncytial virus have been evoked using bacterially expressed G immunogenic domain protein without any adjuvant. (C) 2011 International Union of Biochemistry and Molecular Biology, Inc. Volume 58, Number 2, March/April 2011, Pages 97-102. E-mail: kyusoff@biotech.upm.edu.my

Item Type: Article
Creators:
CreatorsEmail
Jalilian, F. A.UNSPECIFIED
Jahanshiri, F.UNSPECIFIED
Sekawi, Z.UNSPECIFIED
Omar, A. R.UNSPECIFIED
Yusoff, K.UNSPECIFIED
Keywords: protein expression respiratory syncytial virus G immunogenic domain attachment g balb/c mice recombinant protein vaccine candidate escherichia-coli g glycoprotein rsv infection immunization protection Biochemistry & Molecular Biology Biotechnology & Applied Microbiology
Divisions:
Page Range: pp. 97-102
Journal or Publication Title: Biotechnology and Applied Biochemistry
Journal Index: ISI
Volume: 58
Number: 2
Identification Number: https://doi.org/10.1002/bab.19
ISSN: 0885-4513
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/853

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