Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population

Tue Jul 5 18:18:41 2022

(2011) The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population. Molecular and Cellular Biochemistry. pp. 113-118. ISSN 0300-8177

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Abstract

The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that the K121Q variant might be associated with T2D and related metabolic traits in this population. The K121Q genotypes were determined by PCR-restriction fragment length polymorphism in 377 normoglycemic controls and 155 T2D patients. T2D patients had significantly higher values for systolic and diastolic blood pressure, BMI, glucose, cholesterol, triglyceride, LDL, apoB, insulin, and HOMA-IR, and lower levels of HDL than the normoglycemic subjects. The frequency of the Q allele did not differ between T2D and normoglycemic subjects (OR 0.96, 95 CI 0.90-2.00, P = 0.70). The Q allele frequency was 16.5 in T2D and 15.2 in normoglycemic subjects. The ENPP1 genotype (KQ + QQ) was not associated with the systolic and diastolic blood pressure, glucose, triglyceride, cholesterol, LDL-C and HDL-C, apo B, BMI, HOMA-IR, and insulin levels in both normoglycemic and T2D groups. Our results suggest that the ENPP1 121Q allele might not be associated with T2D and related metabolic traits among Iranian subjects.

Item Type: Article
Creators:
CreatorsEmail
Saberi, H.UNSPECIFIED
Mohammadtaghvaei, N.UNSPECIFIED
Gulkho, S.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Mohammadi, M.UNSPECIFIED
Hanachi, P.UNSPECIFIED
Gerayesh-nejad, S.UNSPECIFIED
Zargari, M.UNSPECIFIED
Ataei, F.UNSPECIFIED
Parvaneh, L.UNSPECIFIED
Larijani, B.UNSPECIFIED
Meshkani, R.UNSPECIFIED
Keywords: Insulin resistance Iranian population Type 2 diabetes K121Q ENPP1 homeostasis model assessment insulin-receptor inhibitor membrane glycoprotein pc-1 genetic susceptibility glucose-intolerance japanese population no evidence resistance variant obesity Cell Biology
Divisions:
Page Range: pp. 113-118
Journal or Publication Title: Molecular and Cellular Biochemistry
Journal Index: ISI
Volume: 350
Number: 1-2
Identification Number: https://doi.org/10.1007/s11010-010-0687-z
ISSN: 0300-8177
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/850

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