Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Plasma Myeloperoxidase Activity and Apolipoprotein A-1 Expression in Chronic Hepatitis B Patients

Wed Jun 19 06:44:05 2024

(2011) Plasma Myeloperoxidase Activity and Apolipoprotein A-1 Expression in Chronic Hepatitis B Patients. Archives of Iranian Medicine. pp. 254-258. ISSN 1029-2977

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Background: Hepatitis B virus initiates a complicated cascade process leading to chronic hepatitis B, cirrhosis, and hepatocellular carcinoma. In inflammatory situations, myeloperoxidase is released in plasma and binds to apolipoprotein A-1 in high-density lipoproteins. This study aims to evaluate the level of plasma myeloperoxidase as well as the pattern of plasma proteins in patients with chronic hepatitis B. Methods: Included in this study were 30 male subjects: 19 chronic hepatitis B patients, 6 HBV-related cirrhotic patients, and 5 healthy controls. Plasma myeloperoxidase was measured using enzyme-linked immunosorbent assay. Proteomic analysis of plasma proteins was performed by two-dimensional gel electrophoresis (2-DE) and mass spectrometry. One way ANOVA was used for data analysis. Results: Mean plasma myeloperoxidase levels were higher in patients with liver cirrhosis (65.5 +/- 12.5; P=0.007) and chronic hepatitis B (53.7 +/- 10.6; P=0.18) when compared with healthy subjects (45 +/- 7.6). Moreover, a positive correlation was found between plasma myeloperoxidase levels and hepatic fibrosis stage (r=0.53, P=0.002; r=0.63, P=0.000). Proteomic analysis showed an altered plasma protein pattern in progressive hepatitis B and down-regulation of the major apolipoprotein A-1 along with the appearance of a variety of spots noted to be apolipoprotein A-1isoforms with different molecular masses. Conclusion: In this study, progressive liver injury due to HBV infection correlated with higher plasma myeloperoxidase and an altered plasma apolipoprotein A-1pattern.

Item Type: Article
Mohamadkhani, A.UNSPECIFIED
Montaser-Kouhsari, L.UNSPECIFIED
Keywords: apolipoprotein A-1 chronic hepatitis B myeloperoxidase two-dimensional gel electrophoresis hepatocellular-carcinoma a-i proteome analysis transgenic mice virus infection cirrhosis liver consequences cholesterol impairment General & Internal Medicine
Page Range: pp. 254-258
Journal or Publication Title: Archives of Iranian Medicine
Journal Index: ISI
Volume: 14
Number: 4
ISSN: 1029-2977
Depositing User: مهندس مهدی شریفی

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