Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

qnr Prevalence in Extended Spectrum Beta-lactamases (ESBLs) and None-ESBLs Producing Escherichia coli Isolated from Urinary Tract Infections in Central of Iran

Mon Oct 3 01:58:22 2022

(2011) qnr Prevalence in Extended Spectrum Beta-lactamases (ESBLs) and None-ESBLs Producing Escherichia coli Isolated from Urinary Tract Infections in Central of Iran. Iranian Journal of Basic Medical Sciences. pp. 458-464. ISSN 2008-3866

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Abstract

Objective(s) Extensive use of quinolones has been associated with raising level of resistance. In the current, we focused on assessing the prevalence of Escherichia coli resistance to quinolones and frequency of qnrA, qnrB and qnrS in non ESBLs (extended spectrum beta-lactamases) and ESBLs producing E. coli with blaSHV and blaTEM. Materials and Methods One hundred and fifty E. coli isolates were identified during Mar. 2007 to Apr. 2008 in Milad (Tehran) hospital. They were tested for ESBLs production as well as quinolone resistance. PCR was performed for detection of blaSHV and blaTEM as well as qnrA, B and S. Results Of 150 isolates, forty-two (28) ESBLs producing and one hundred and eight (72) non-ESBLs producing E. coli were identified. 64.2 (n= 24) of E. coli producing ESBLs and 4.62 (n= 5) of non-ESBLs E. coli were resistance to ciprofloxacin. 95.2 (n= 40) and 26.1 (n= 11) of the isolates harbored blaTEM and blaSHV, respectively. 23.8 (n= 10) had both genes. 37.5 (n= 9) and 20.8 (n= 4) of ESBLs producing E. coli were positive for qnrA and qnrB respectively. qnrS was not identified in any isolate. Conclusion Our study showed high frequency of ESBLs producing E. coli as well as quinolone resistance genes (qnrA, qnrB) in Milad hospital.

Item Type: Article
Creators:
CreatorsEmail
Pakzad, I.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Abtahi, H.UNSPECIFIED
Rahbar, M.UNSPECIFIED
Jamshidi, N. M.UNSPECIFIED
Keywords: Ciprofloxacin Iran Resistance mediated quinolone resistance klebsiella-pneumoniae enterobacteriaceae genes emergence strains Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 458-464
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 14
Number: 5
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/833

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