Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Phenotypic and genotypic evaluation of fluoroquinolone resistance in clinical isolates of Staphylococcus aureus in Tehran

Sat Jun 25 09:14:08 2022

(2011) Phenotypic and genotypic evaluation of fluoroquinolone resistance in clinical isolates of Staphylococcus aureus in Tehran. Medical Science Monitor. PH71-PH74. ISSN 1234-1010

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Abstract

Background: Fluoroquinolones are broad-spectrum antibiotics widely used in the treatment of bacterial infections such as Staphylococcus aureus isolates. Resistance to these antibiotics is increasing. Material/Methods: The occurrence of mutations in the grlA and gyrA loci were evaluated in 69 fluoroquinolone-resistant S. aureus isolates from 2 teaching hospitals of Tehran University of Medical Sciences. Results: Out of the 165 S. aureus isolates, 87 (52.7) were resistant to methicillin and 69 (41.8) were resistant to fluoroquinolone. Fluoroquinolone-resistant S. atoms isolates had a mutation at codon 80 in the grlA gene and different mutational combinations in the gyrA gene. These mutational combinations included 45 isolates at codons 84 and 86,23 isolates at codons 84,86 and 106 and 1 isolate at codons 84, 86 and 90. Fluoroquinolone-resistant S. aureus isolates were clustered into 33 PFGE types. Conclusions: The findings of this study show that the fluoroquinolone-resistant S. aureus strains isolated in the teaching hospitals in Tehran had multiple mutations in the QRDRs region of both grlA and gyrA genes.

Item Type: Article
Creators:
CreatorsEmail
Aligholi, M.UNSPECIFIED
Mirsalehian, A.UNSPECIFIED
Halimi, S.UNSPECIFIED
Imaneini, H.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Jabalameli, F.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Mohajer, B.UNSPECIFIED
Abdollahi, A.UNSPECIFIED
Emaneini, M.UNSPECIFIED
Keywords: fluoroquinolone resistance Staphylococcus aureus QRDR gram-positive cocci quinolone resistance antimicrobial susceptibility molecular characterization gyra mutations grla ciprofloxacin genes iran Research & Experimental Medicine
Divisions:
Page Range: PH71-PH74
Journal or Publication Title: Medical Science Monitor
Journal Index: ISI
Volume: 17
Number: 9
Identification Number: https://doi.org/10.12659/msm.881920
ISSN: 1234-1010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/827

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