Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Lipid-lowering effect of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in hyperlipidemic rats

Wed Nov 30 07:00:13 2022

(2011) Lipid-lowering effect of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in hyperlipidemic rats. Journal of Medicinal Plants Research. pp. 4918-4924. ISSN 1996-0875

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Abstract

Artichoke (Cynara scolymus L.) is full of natural antioxidants and has a lipid-lowering effect. The aim of this study was to investigate the effect of artichoke on the liver phosphatidate phosphohydrolase (PAP), plasma lipid levels, plasma malondialdehyde (MDA), and plasma antioxidant in hyperlipidemic rats. Male rats were fed by standard pellet diet (Group 1), standard diet supplemented with 10 artichoke (Group 2), lipogenic diet (containing sunflower oil, cholesterol and ethanol) plus 10 artichoke (Group 3) and only lipogenic diet (Group 4). On day 60 of the experiment, liver PAP activity, liver triglyceride (TG), plasma lipids, plasma MDA, and plasma antioxidant levels were measured. PAP activity, liver TG, the ratio of total cholesterol (TC) to high density lipoprotein (HDL) cholesterol, plasma TC and TG levels were significantly decreased due to artichoke treatment in Groups 2 and 3 compared to Groups 1 and 4, respectively. Significant reduction in plasma MDA and significant elevation in plasma antioxidant power observed in Groups 2 and 3 compared to Groups 1 and 4, respectively. The results clearly indicated that artichoke can be useful for the reduction of PAP activity and liver TG. Also, artichoke has beneficial effects in the controlling of hyperlipidemia, abnormalities in lipid profiles and oxidative stress in hyperlipidemic regimes.

Item Type: Article
Creators:
CreatorsEmail
Heidarian, E.UNSPECIFIED
Jafari-Dehkordi, E.UNSPECIFIED
Seidkhani-Nahal, A.UNSPECIFIED
Keywords: Artichoke hyperlipidemia liver triglyceride plasma lipids phosphatidate phosphohydrolase cynara-scolymus l. leaf extract oxidative stress in-vitro lipoprotein phosphatases inhibition leaves roles cells Pharmacology & Pharmacy
Divisions:
Page Range: pp. 4918-4924
Journal or Publication Title: Journal of Medicinal Plants Research
Journal Index: ISI
Volume: 5
Number: 19
ISSN: 1996-0875
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/823

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