Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Nuclear factor kappa B1/RelA mediates the inflammation and/or survival of human airway exposed to sulfur mustard

Thu Jun 30 11:23:46 2022

(2011) Nuclear factor kappa B1/RelA mediates the inflammation and/or survival of human airway exposed to sulfur mustard. Journal of Receptors and Signal Transduction. pp. 367-373. ISSN 1079-9893

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Abstract

Context: Sulfur mustard (SM) is known as an effective chemical agent and was used in the 1980s during the Iran-Iraq war against Iranians. At the present time, there are more than 40,000 people suffering from pulmonary lesions due to mustard gas in Iran. Though much is known about the gross pathology of SM damage, the molecular and cellular basis for this pathology is not well understood. Objective: One of the most important protein groups involved in inflammatory responses is nuclear factor.B protein (NF-kB1) family. They belong to the category of DNA-binding protein factors necessary for transcription of many proinflammatory molecules. In our research, we examined the role of NF-kB1/RelA in the pathophysiology of the lung. Materials and methods: We investigated 10 normal individuals and 20 SM induced patients. Expression of NF-kB1/RelA in controls and the SM exposed samples was measured by real-time polymerase chain reaction and localization of NF-kB1 protein was detected by immunohistochemistry staining. Results: Our results revealed that expression levels of NF-kB1 and RelA were upregulated 0.64-6.50 fold and 0.83-8.34 fold, respectively, in the SM exposed patients in comparison with control samples. Discussion and conclusion: As far as we know, this is the first finding of induction of NF-kB in patients exposed to SM. NF-kB1/RelA may play a major role in inflammation induced by mustard gas or even in cell survival in the bronchial wall of affected patients.

Item Type: Article
Creators:
CreatorsEmail
Yazdani, S.UNSPECIFIED
Karimfar, M. H.UNSPECIFIED
Fooladi, A. A. I.UNSPECIFIED
Mirbagheri, L.UNSPECIFIED
Ebrahimi, M.UNSPECIFIED
Ghanei, M.UNSPECIFIED
Nourani, M. R.UNSPECIFIED
Keywords: NF-kB1 RelA bronchial wall sulfur mustard nf-kappa-b obstructive pulmonary-disease dependent gene-expression DNA-binding activity transcription factors lung inflammation bronchiolitis obliterans epithelial-cells activation pathway Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 367-373
Journal or Publication Title: Journal of Receptors and Signal Transduction
Journal Index: ISI
Volume: 31
Number: 5
Identification Number: https://doi.org/10.3109/10799893.2011.602415
ISSN: 1079-9893
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/822

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