Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

EFFECT OF TANNIN EXTRACT AGAINST PSEUDOMONAS AERUGINOSA PRODUCING METALLO BETA-LACTAMASE

(2012) EFFECT OF TANNIN EXTRACT AGAINST PSEUDOMONAS AERUGINOSA PRODUCING METALLO BETA-LACTAMASE. Journal of Biological Regulators and Homeostatic Agents. pp. 231-236. ISSN 0393-974X

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Abstract

Carbapenems are the most potent beta-lactam agents with a broad-spectrum activity against Gram-negative and Gram-positive bacteria. They are stable in the presence of penicillinases and cephalosporinases. This study was focused on frequency of metallo beta- lactamase (MBL) among Pesudomonas aeruginosa strains isolated in patients with urinary tract infection, effect of tannin against PA positive strains which produced blaVIM or blaIMP and both of these genes (Species). Detection of MBL was performed by phonotypic and genotypic methods. Tannin extract was tested against P. aeruginosa producing MBL. During the study period, 240 P. aeruginosa isolates were identified. Among them 64 (26.6) isolates were imipenem non-susceptible and confirmed by imipenem/EDTA. Our results revealed that the growth of blaVIM positive P. aeruginosa inhibited at 15 mu g/ml concentration. The experiment repeated for blaIMP-positive P. aeruginosa and P. aeruginosa which harbored blaIMP and blaVIM, the results showed 35 mu g/ml was the best concentration for inhibition of P. aeruginosa-positive blaIMP and also P. aeruginosa blaIMP and blaVIM. In conclusion, tannin was effective against P. aeruginosa producing blaVIM and blaIMP and both of them so it can be substituted with common antibiotics. The result showed significantly P. aeruginosa-harbored blaIMP was more responsible for imipenem resistance than P. aeruginosa-positive blaVIM. Interestingly, tannin was more effective against MBL - P. aeruginosa in comparison with current antibiotics.

Item Type: Article
Keywords: Pseudomonas aeruginosa tannin urinary tract infection prevalence resistance outbreak strains Endocrinology & Metabolism Immunology Research & Experimental Medicine Physiology
Page Range: pp. 231-236
Journal or Publication Title: Journal of Biological Regulators and Homeostatic Agents
Journal Index: ISI
Volume: 26
Number: 2
ISSN: 0393-974X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/793

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