Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients

(2012) A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients. Burns. pp. 378-382. ISSN 0305-4179

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Abstract

Infections due to Staphylococcus aureus have become increasingly common among burn patients. The antibiotic resistance profile of S. aureus isolates and inducible resistance against clindamycin were investigated in this study. The presence of mecA gene, mupA gene and macrolide resistance genes were detected using PCR and multiplex-PCR. The resistance rate to methicillin, erythromycin and mupirocin were 58.5, 58 and 40, respectively. The prevalence of constitutive and inducible resistance among macrolide resistant isolates was 75 and 25, respectively. Ninety five percent of the isolates were positive for one or more erm genes. The most common genes were ermA (75), ermC (72) and ermB (69), respectively. The ermA gene predominated in the strains with the inducible phenotype, while ermC was more common in the isolates with the constitutive phenotype. The msrA gene was only found in one MRSA isolate with the constitutive phenotype. A total of 27 isolates (25) carried the mupA gene. All the mupirocin resistant isolates and almost all the erythromycin resistant isolates were also resistant against methicillin which may indicate an outbreak of MRSA isolates with high-level mupirocin and erythromycin resistance in the burn unit assessed. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.

Item Type: Article
Keywords: Staphylococcus aureus Inducible resistance Macrolide resistance Mupirocin resistance Burnt patients coagulase-negative staphylococci multiplex pcr methicillin unit community genes infection outbreak tehran expression General & Internal Medicine Dermatology Surgery
Page Range: pp. 378-382
Journal or Publication Title: Burns
Journal Index: ISI
Volume: 38
Number: 3
Identification Number: https://doi.org/10.1016/j.burns.2011.09.004
ISSN: 0305-4179
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/792

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