Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein

Sun Aug 14 01:20:49 2022

(2013) Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein. Disease Markers. p. 8. ISSN 0278-0240

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Abstract

Introduction. Cardioprotective effect of high density lipoprotein (HDL) is, in part, dependent on its related enzyme, paraoxonase 1 (PON1). Fatty acid composition of HDL could affect its size and structure. On the other hand, PON1 activity is directly related to the structure of HDL. This study was designed to investigate the association between serum PON1 activity and fatty acid composition of HDL in healthymen. Methods. One hundred and forty healthy men participated in this research. HDL was separated by sequential ultracentrifugation, and its fatty acid composition was analyzed by gas chromatography. PON1 activity was measured spectrophotometrically using paraxon as substrate. Results. Serum PON1 activity was directly correlated with the amount of stearic acid and dihomo-gamma-linolenic acid (DGLA). PON1/HDL-C was directly correlated with the amount of miristic acid, stearic acid, and DGLA and was inversely correlated with total amount of.. 6 fatty acids of HDL. Conclusion. The fatty acid composition of HDL could affect the activity of its associated enzyme, PON1. As dietary fats are the major determinants of serum lipids and lipoprotein composition, consuming some special dietary fatty acids may improve the activity of PON1 and thereby have beneficial effects on health.

Item Type: Article
Creators:
CreatorsEmail
Boshtam, M.UNSPECIFIED
Razavi, A. E.UNSPECIFIED
Pourfarzam, M.UNSPECIFIED
Ani, M.UNSPECIFIED
Naderi, G. A.UNSPECIFIED
Basati, G.UNSPECIFIED
Mansourian, M.UNSPECIFIED
Dinani, N. J.UNSPECIFIED
Asgary, S.UNSPECIFIED
Abdi, S.UNSPECIFIED
Keywords: mean particle-size pon1 activity oxidative inactivation plasma lipids cholesterol gene rich Biotechnology & Applied Microbiology Genetics & Heredity Research & Experimental Medicine Pathology
Divisions:
Page Range: p. 8
Journal or Publication Title: Disease Markers
Journal Index: ISI
Identification Number: https://doi.org/10.1155/2013/612035
ISSN: 0278-0240
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/746

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