Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Serum gastrin 17, pepsinogen I and pepsinogen II in atrophic gastritis patients living in North-East of Iran

Mon May 20 16:03:00 2024

(2013) Serum gastrin 17, pepsinogen I and pepsinogen II in atrophic gastritis patients living in North-East of Iran. Journal of Research in Medical Sciences. pp. 225-229. ISSN 1735-1995

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Background: Gastric carcinoma is the second most common cause of cancer-related death in Iran. It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin 17 (G-17), pepsinogen I (P-I), and pepsinogen II (P-II). The aim of this study was to investigate the diagnostic accuracy of these serum biomarkers in the early detection of atrophic gastritis. Materials and Methods: A total of 132 dyspeptic patients underwent upper endoscopy and biopsies were taken. The biopsy specimens were evaluated as the gold standard according to operative link for gastritis assessment staging system. Serum levels of G-17, P-I, and P-II were investigated using enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) analysis was used to calculate the diagnostic indices and optimal cut-off values using Statistical Package for the Social Sciences SPSS statistical software. Results: A total of 67 men and 65 women were analyzed, among which 48 (36.4) had atrophic gastritis. The mean age was 45.8 (+/- 15.8) years. ROC curve analysis demonstrated that the biomarkers (including pepsinogen I/II P-I/II ratio), except for P-I, are diagnostically significant in detecting gastric atrophy. The area under the curve (95% confidence interval CI) for G-17, P-I, P-II, and P-I/II ratio were 0.65 (0.55-0.76), 0.42 (0.32-0.53), 0.62 (0.52-0.72), and 0.61 (0.50-0.72), respectively. However, the diagnostic indices were low (sensitivity <50%, specificity <90%). The prevalence of Helicobacter pylori infection was significantly higher in patients with atrophy against those without atrophy (75.0% vs. 57.4%, P value <0.0001). Conclusion: In the studied population, the serum biomarkers of atrophic gastritis are not useful screening tests due to their low sensitivity.

Item Type: Article
Attaranzadeh, A.UNSPECIFIED
Keywords: Atrophic gastritis dyspepsia gastrin 17 pepsinogen I pepsinogen II helicobacter-pylori serological markers cancer antibodies risk General & Internal Medicine
Page Range: pp. 225-229
Journal or Publication Title: Journal of Research in Medical Sciences
Journal Index: ISI
Volume: 18
Number: 3
ISSN: 1735-1995
Depositing User: مهندس مهدی شریفی

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