Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Expression patterns of Toll like receptor (TLR)-2, TLR-4 and myeloid differentiation primary response gene 88 (MYD88) in renal transplant patients developing allograft dysfunction; a cohort study

Tue Dec 6 01:09:21 2022

(2018) Expression patterns of Toll like receptor (TLR)-2, TLR-4 and myeloid differentiation primary response gene 88 (MYD88) in renal transplant patients developing allograft dysfunction; a cohort study. Transplant Immunology. pp. 26-31. ISSN 0966-3274

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Abstract

This cohort intends to determine the sequential dynamic changes in Toll-like receptor (TLR)-4, TLR-2, and myeloid differentiation primary response gene 88 (MYD88) mRNA expressions in PBMCs and biopsy samples from kidney allograft recipients in relation to graft function. This study enrolled 52 renal transplant patients, 27 with well functioning graft (WFG) and 25 graft dysfunction (GD). Peripheral blood samples pre- and post-transplantation (days 2, 90 and 180) were collected to analyze mRNA expression levels of TLR-2, TLR-4, and MYD88 genes in relation to allograft function during one-year follow up. The mean dynamic changes of post-transplant TLR-2, TLR-4, and MYD88 mRNA expressions were significantly higher in GD compared to WFG patients (P = .001). ROC curve analysis based on glomerular filtration rate (GFR) index showed the area under curve (AUC) values for the genes: TLR-2(0.89;P < .001), TLR-4(0.86;P < .001), and MYD88(0.75;P = .003) in the third month post-transplantation for GD diagnosis. The calculated AUCs for the expressions of genes in allograft biopsies were 0.94(TLR-2), 0.95(TLR-4), and 0.98(MYD88) in the sixth month post-transplant based on pathology report (P < .001). Our results indicate that sequential monitoring of the expression patterns of TLR-2, TLR-4, and MYD88 in PBMCs and biopsy samples could be considered as predictive biomarkers for early and late kidney allograft function.

Item Type: Article
Creators:
CreatorsEmail
Hosseinzadeh, M.UNSPECIFIED
Ahmadpoor, P.UNSPECIFIED
Yekaninejad, M. S.UNSPECIFIED
Pourrezagholi, F.UNSPECIFIED
Foroughi, F.UNSPECIFIED
Ghorbanpour, M.UNSPECIFIED
Barabadi, M.UNSPECIFIED
Shahbaz, S. K.UNSPECIFIED
Solgi, G.UNSPECIFIED
Amirzargar, A.UNSPECIFIED
Keywords: Kidney transplantation Graft dysfunction Acute rejection Toll like receptors ischemia-reperfusion injury kidney-transplantation rejection tolerance inflammation Immunology Transplantation
Divisions:
Page Range: pp. 26-31
Journal or Publication Title: Transplant Immunology
Journal Index: ISI
Volume: 48
Identification Number: https://doi.org/10.1016/j.trim.2018.02.005
ISSN: 0966-3274
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/72

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