Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

DISTRIBUTION OF EXTENDED SPECTRUM BETA-LACTAMASE RESISTANCE GENES AMONG NOSOCOMIAL IMIPENEM RESISTANT A. BAUMANNH STRAINS HARBORING BLA(OXA-23) CARBAPENEMASES ISOLATED FROM ILAM AND TEHRAN

(2013) DISTRIBUTION OF EXTENDED SPECTRUM BETA-LACTAMASE RESISTANCE GENES AMONG NOSOCOMIAL IMIPENEM RESISTANT A. BAUMANNH STRAINS HARBORING BLA(OXA-23) CARBAPENEMASES ISOLATED FROM ILAM AND TEHRAN. Journal of Biological Regulators and Homeostatic Agents. pp. 883-889. ISSN 0393-974X

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Abstract

Antimicrobial susceptibility and ESBLs genes of 42 imipenem resistant A. baumannii carried out by DDST and PCR. The most antimicrobial agents against A. baumannii strains, harboring bla(OXA-23-like) carbapenemases, were meropenem (33.4), piperacillin-tazobactam (23.9), ceftazidime (14.3) and gatifoxacin (19.1), respectively. All the 42 isolates harbored the bla(TEM) gene, but the bla(SHV and VEB) genes were not present among all the isolates. With the exception of seven isolates, all the A. baumannii strains harbor bla(TEM) showed ESBL positivity in DDST. The result of this study show that resistance against antimicrobial agents, especially carbapenems, has increased and that bla(TEM) harboring A. baumannii strains can be help the blaoxmike carbapenemase genes to code for resistance against carbapenem antibiotics.

Item Type: Article
Keywords: A. baumannii ESBL OXA-carbapenemase genes acinetobacter-baumannii medical-center emergence hospitals outbreak patterns iran Endocrinology & Metabolism Immunology Research & Experimental Medicine Physiology
Divisions:
Page Range: pp. 883-889
Journal or Publication Title: Journal of Biological Regulators and Homeostatic Agents
Journal Index: ISI
Volume: 27
Number: 3
ISSN: 0393-974X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/719

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