Repository of Research and Investigative Information

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Ilam University of Medical Sciences

Asthma in Children in Relation to Pre-term Birth and Fetal Growth Restriction

Sun Aug 14 02:51:10 2022

(2013) Asthma in Children in Relation to Pre-term Birth and Fetal Growth Restriction. Maternal and Child Health Journal. pp. 1119-1129. ISSN 1092-7875

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Abstract

To assess the impact of parental asthma on risk of pre-term birth (PTB) and intrauterine growth restriction, and their subsequent association with childhood asthma. Three sequential cross-sectional surveys were conducted in 1993 (3,746), 1998 (1,964) and 2006 (1,074) in the same 15 schools among 5-11 year old children in Merseyside using the same respiratory health questionnaire completed by parents (sample size in brackets). Between 1993 and 2006, prevalence of PTB varied between 12.4 and 15.2 , and of small for gestational age (SGA or growth restricted) babies between 2.1 and 4.6 , and maternal asthma prevalence between 8.1 and 13.4 . For the combined surveys mothers with asthma were more likely to have a PTB than non-asthmatic mothers (OR 1.39, 95 CI 1.10-1.95, p < 0.001), and in the 2006 survey were more likely to have an SGA baby. 40.9 of PTBs of asthmatic mothers developed doctor diagnosed asthma compared to 34.3 for term babies (adjusted OR 1.65, 1.34-2.04, p < 0.001). The corresponding estimates for the symptom triad of cough, wheeze and breathlessness were 19.4 and 17.6 (adjusted OR 1.78, 0.79-3.98). Conversely SGA babies were less likely to develop doctor diagnosed asthma (adjusted OR 0.49, 0.27-0.90, p < 0.021), or the symptom triad of cough, wheeze and breathlessness (adjusted OR 0.22, 0.05-0.97, p < 0.043), whether or not the mother was asthmatic. Maternal asthma is an independent risk factor for PTB which predisposes to childhood asthma. Intrauterine growth restriction was protective against childhood asthma.

Item Type: Article
Creators:
CreatorsEmail
Koshy, G.UNSPECIFIED
Akrouf, K. A. S.UNSPECIFIED
Kelly, Y.UNSPECIFIED
Delpisheh, A.UNSPECIFIED
Brabin, B. J.UNSPECIFIED
Keywords: Asthma Pre-term birth Small for gestational age Maternal asthma Smoking Children maternal asthma respiratory morbidity childhood asthma parental asthma 1st year smoking weight merseyside pregnancy schoolchildren Public, Environmental & Occupational Health
Divisions:
Page Range: pp. 1119-1129
Journal or Publication Title: Maternal and Child Health Journal
Journal Index: ISI
Volume: 17
Number: 6
Identification Number: https://doi.org/10.1007/s10995-012-1114-8
ISSN: 1092-7875
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/716

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