Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients

Mon May 20 06:06:57 2024

(2013) Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients. Iranian Red Crescent Medical Journal. pp. 701-703. ISSN 2074-1804

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Background: Toxoplasmosis is caused by the Toxoplasmagondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Diabetes is an important factor that increases susceptibility and risk of various infections in the host. Objectives: The present study focused on the serologic detection of Toxoplasma gondii infection in diabetic patients. Materials and Methods: Through a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method. Results: The prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43 and 38 respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR = 2.21, 95 CI; 1.6 - 3.7, P = 0.001). Conclusions: Diabetes may be caused by Toxoplasma gondii. Presence of T. gondii in the pancreas at the same time could directly undermines the pancreas cells. When beta cells are destroyed, insulin secretion would then be affected. Probably the destruction of T. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes.

Item Type: Article
Keywords: Diabetes Infection Serum Toxoplasma gondii congenital toxoplasmosis prevalence effector cells General & Internal Medicine
Page Range: pp. 701-703
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 15
Number: 8
Identification Number:
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی

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