Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Association of the Human Leukocyte Antigen (HLA) with the Pathogenesis of Helicobacter pylori

Sun Aug 14 02:48:12 2022

(2013) The Association of the Human Leukocyte Antigen (HLA) with the Pathogenesis of Helicobacter pylori. Journal of Pure and Applied Microbiology. pp. 2183-2189. ISSN 0973-7510

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Abstract

H. pylori pathogenesis is related to various virulence factor which some of them involved to adhesions. Urease as a main pathogenecity factor to attach to HLA-II is expressed on the surface of Gastric Epithelial Cells (GECs). Apoptosis induced by caspase3 activation as a result of urease effects on Spermine-Spermidine cycle. There is a contribution of HLA-DQA1 gene to the host's response against H. pylon. HLA allele type as an immune-genetic factors are related to host susceptibility to H. pylori. HLA-DQA1 might be contributed to the susceptibility or resistance to H. pylori infection. Based on the existed evidences the current review aimed to evaluate the results obtained by different studies carried out so far on correlation of human HLA and the pathogenesis of the H. pylori in gastric epithelial cells.

Item Type: Article
Creators:
CreatorsEmail
Azizian, R.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Azizian, M.UNSPECIFIED
Keywords: Human Leukocyte Antigen Pathogenesis and Helicobacter pylori gastric epithelial-cells idiopathic thrombocytopenic purpura human dendritic cells costimulatory molecules surface localization infection urease gene activation expression Biotechnology & Applied Microbiology Microbiology
Divisions:
Page Range: pp. 2183-2189
Journal or Publication Title: Journal of Pure and Applied Microbiology
Journal Index: ISI
Volume: 7
Number: 3
ISSN: 0973-7510
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/708

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