Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of chemokines and prolactin with cherry angioma in a sulfur mustard exposed population - Sardasht-Iran cohort study

Mon Oct 3 01:01:25 2022

(2013) Association of chemokines and prolactin with cherry angioma in a sulfur mustard exposed population - Sardasht-Iran cohort study. International Immunopharmacology. pp. 991-995. ISSN 1567-5769

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Abstract

Exposure to SM leads to short and long term adverse effects on various organs including the skin. Cherry angioma is one of the late skin disorders in SM exposed individuals. The pathogenesis of abnormal angiogenesis in cherry angioma is not well known but the role of inflammatory mediators and certain hormones, including prolactin, in the regulation of angiogenesis in other diseases has been reported. Alterations in serum levels of prolactin and chemokines in SM-exposed victims and the impact on angiogenesis are indications of the role in SM-induced cherry angioma. As part of the SICS, this study seeks to evaluate the possible association of prolactin and chemokines in the emergence of SM-induced cherry angioma. The serum concentrations of prolactin, IL-8/CXCL8, RANTES/CCL5, MCP-1/CCL2, and fractalkine/CX3CL1 were titrated using sandwich ELISA technique. There was a significant difference in the level of prolactin between the exposed subgroups (with cherry angioma n = 72; mean: 10.13) and without cherry angioma (n = 268; mean: 13.13, p<0.0096). Median of the serum levels of CCL2 in the exposed patients with cherry angioma was significantly higher than exposed patients without cherry angioma (median = 203.5 pg/ml and median = 187.10 pg/ml respectively, p=0.035). There was no significant difference in the serum levels of IL-8, RANTES and CX3L1 between the exposed subgroups with cherry angioma and without cherry angioma. This finding serves as a basis for further research on the molecular mechanisms and pathways involved in the pathogenesis of cherry angioma and other related disorders. (C) 2013 Elsevier B.V. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Askari, N.UNSPECIFIED
Vaez-Mandavi, M. R.UNSPECIFIED
Moaiedmohseni, S.UNSPECIFIED
Khamesipour, A.UNSPECIFIED
Soroush, M. R.UNSPECIFIED
Moin, A.UNSPECIFIED
Jalaie, S.UNSPECIFIED
Ghazanfari, Z.UNSPECIFIED
Faghihzadeh, E.UNSPECIFIED
Ghazanfari, T.UNSPECIFIED
Keywords: Mustard gas Cherry angioma Chemokines Prolactin Sardasht-Iran cohort study endothelial-cells in-vivo angiogenesis cancer skin tumorigenesis veterans growth mcp-1 ccr2 Immunology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 991-995
Journal or Publication Title: International Immunopharmacology
Journal Index: ISI
Volume: 17
Number: 3
Identification Number: https://doi.org/10.1016/j.intimp.2012.12.016
ISSN: 1567-5769
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/697

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