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Ilam University of Medical Sciences

A Case-Control Study on the Association of Common Variants of CAPN10 Gene and the Risk of Type 2 Diabetes in an Iranian Population

Sun Sep 25 09:22:24 2022

(2014) A Case-Control Study on the Association of Common Variants of CAPN10 Gene and the Risk of Type 2 Diabetes in an Iranian Population. Clinical Laboratory. pp. 663-670. ISSN 1433-6510

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Abstract

Background: Calpain-10 is a ubiquitously expressed protease that serves as an intracellular calcium-dependent cysteine protease and is regarded to be one of the candidate genes for type 2 diabetes mellitus (T2DM). We aimed to identify the association of the common variants of this gene and the risk of T2DM in the Kurdish ethnic group of Iran. Methods: Study groups included 173 T2DM and 173 normoglycemic subjects. Genotyping was determined by PCR-RFLP. Genotypic and allelic frequencies were then evaluated. Data was analyzed using SPSS software. Results: The allelic frequency of the A-allele of SNP-43 variant was significantly different (p = 0.01) between case and control groups (18 vs. 11). The genotype frequencies for SNP-43 did not show any significant difference between case and control individuals. However, the dominant model of SNP-43 was found to be significantly associated with T2DM (OR = 1.75, 95 CI = 1.06 - 2.89, p < 0.029). The distribution and allele frequency of other SNPs (SNP-19 and -63) did not show any significant difference between the study groups. For SNP-43, fasting serum insulin (p = 0.043) and HOMA-IR (p = 0.026) were higher in the control subjects with the GA+AA genotype when compared with the GG genotype. Among the T2DM subjects, there was no significant difference in any of the clinical or biochemical parameters between the GG and GA+AA genotypes of SNP-43. Normoglycemic subjects carrying the 2R13R+3R13R genotypes of SNP-19 had significantly lower HDL-C (p = 0.034) as compared with those with the 2R/2R genotype. In T2DM subjects, no significant difference was found in any of the clinical or biochemical parameters between 2R/2R and 2R13R+3R/3R genotypes. T2DM subjects carrying the CT+TT genotypes of SNP-63 variation had significantly higher LDL-C (p = 0.015) as compared with those with the CC genotype. In normoglycemic subjects, no significant difference was found in any of the clinical or biochemical parameters between CC and CT+TT genotypes. Conclusions: Our findings revealed that there is an association between the SNP-43, but not SNP-19 and -63, and T2DM in the Kurdish ethnic group of West Iran.

Item Type: Article
Creators:
CreatorsEmail
Maleki, F.UNSPECIFIED
Haghani, K.UNSPECIFIED
Shokouhi, S.UNSPECIFIED
Mahmoodi, K.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Mahdieh, N.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Keywords: type 2 diabetes Calpain-10 Kurd polymorphism single nucleotide polymorphisms calpain-10 gene insulin-resistance mellitus japanese glucose susceptibility prevalence expression caucasians Medical Laboratory Technology
Divisions:
Page Range: pp. 663-670
Journal or Publication Title: Clinical Laboratory
Journal Index: ISI
Volume: 60
Number: 4
Identification Number: https://doi.org/10.7754/Clin.Lab.2013.130630
ISSN: 1433-6510
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/681

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