Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Predictive Factors of Survival Time of Breast Cancer in Kurdistan Province of Iran between 2006-2014: A Cox Regression Approach

Sun Aug 14 01:53:51 2022

(2014) Predictive Factors of Survival Time of Breast Cancer in Kurdistan Province of Iran between 2006-2014: A Cox Regression Approach. Asian Pacific Journal of Cancer Prevention. pp. 8483-8488. ISSN 1513-7368

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Abstract

Background: Breast cancer is the most common cancer and the second most common cause of cancer-induced mortalities in Iranian women, following gastric carcinoma. The survival of these patients depends on several factors, which are very important to identify in order to understand the natural history of the disease. Materials and Methods: In this retrospective study, 313 consecutive women with pathologically-proven diagnosis of breast cancer who had been treated during a seven-year period (January 2006 until March 2014) at Towhid hospital, Sanandaj city, Kurdistan province of Iran, were recruited. The Kaplan-Meier method was used for data analysis, and finally those factors that showed significant association on univariate analysis were entered in a Cox regression model. Results: the mean age of patients was 46.10 +/- 10.81 years. Based on Kaplan-Meier method median of survival time was 81 months and 5 year survival rate was 75+/- 0.43. Tumor metastasis (HR=9.06, p=0.0001), relapse (HR=3.20, p=0.001), clinical stage of cancer (HR=2.30, p=0.03) and place of metastasis (p=0.0001) had significant associations with the survival rate variation. Patients with tumor metastasis had the lowest five-year survival rate (37) and among them patients who had brain metastasis were in the worst condition (5 year survival rate=11+/- 0.10). Conclusions: Our findings support the observation that those women with higher stages of breast malignancies (especially with metastatic cancer) have less chance of surviving the disease. Furthermore, screening programs and early detection of breast cancer may help to increase the survival of those women who are at risk of breast cancer.

Item Type: Article
Creators:
CreatorsEmail
Karimi, A.UNSPECIFIED
Delpisheh, A.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Saboori, H.UNSPECIFIED
Rahimi, E.UNSPECIFIED
Keywords: Breast cancer survival prognostic factors Iran disease-free survival prognostic-factors models Oncology
Divisions:
Page Range: pp. 8483-8488
Journal or Publication Title: Asian Pacific Journal of Cancer Prevention
Journal Index: ISI
Volume: 15
Number: 19
Identification Number: https://doi.org/10.7314/apjcp.2014.15.19.8483
ISSN: 1513-7368
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/678

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