Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of plasma leptin, homocysteine and nitric oxide levels with the presence and instability of coronary artery disease

Mon Oct 3 12:51:23 2022

(2014) Association of plasma leptin, homocysteine and nitric oxide levels with the presence and instability of coronary artery disease. Biomarkers in Medicine. pp. 405-412. ISSN 1752-0363

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Abstract

Aim: Leptin and total homocysteine (tHcy) may participate in the pathogenesis of coronary artery disease (CAD) through nitric oxide (NO) depletion. We sought to investigate whether leptin, tHcy and NO are suitable predictors of CAD. Patients & methods: This study contained 50 control subjects and 50 stable and 50 unstable angina patients. Plasma leptin, tHcy and NO levels were determined using enzyme immunoassay, HPLC fluorescence and spectrophotometric methods, respectively. Other conventional risk factors were also determined. Results: Leptin and tHcy levels were highest in unstable angina patients, followed by stable angina patients and then controls (p < 0.001). Controls had significantly higher NO than patients (p <0.001). Leptin and tHcy had a positive and NO a negative association with the presence of CAD. Conclusions: Some athrogenic effects of leptin may be mediated by affecting tHcy and NO levels. Plasma leptin, tHcy and NO levels showed significant contribution to CAD prediction and discrimination.

Item Type: Article
Creators:
CreatorsEmail
Basati, G.UNSPECIFIED
Razavi, A. E.UNSPECIFIED
Abdi, S.UNSPECIFIED
Sarrafzedegan, N.UNSPECIFIED
Keywords: CAD homocysteine leptin nitric oxide stable unstable heart-disease endothelial dysfunction oxidative stress myeloperoxidase levels serum leptin risk resistance receptor obesity atherosclerosis Research & Experimental Medicine
Divisions:
Page Range: pp. 405-412
Journal or Publication Title: Biomarkers in Medicine
Journal Index: ISI
Volume: 8
Number: 3
Identification Number: https://doi.org/10.2217/bmm.13.131
ISSN: 1752-0363
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/669

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