Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Relationship Between Selenium Levels and Breast Cancer: A Systematic Review and Meta-Analysis

(2014) The Relationship Between Selenium Levels and Breast Cancer: A Systematic Review and Meta-Analysis. Biological Trace Element Research. pp. 1-7. ISSN 0163-4984

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Breast cancer is the most common cancer type. In several studies, hints have been provided that there is a correlation between selenium deficiency and the incidence of breast cancer. Findings of these published reports are, however, inconsistent. This study serves as a pioneering study aiming at combining the results of studies using a meta-analytic method. A total of 16 articles published between 1980 and 2012 worldwide were selected through searching PubMed, Scopus, and Google scholar databases, and the information were analyzed using a meta-analytic method random effects model. I (2) statistics were used to examine heterogeneity. The information was then analyzed by STATA version 12. In this study, due to the non-uniform methods used to measure selenium concentrations, selenium levels were measured in the various subgroups in both case and control groups. There were significant correlations between selenium concentration and breast cancer P < 0.05. Hence, the mean risk differentiating criteria were estimated to be 0.63 95 % confidence interval 95 CI] 0.93 to 0.32] in serum and toenails. Subgroup analysis showed that the value in toenails was -0.07 95% CI -0.16 to 0.03 and in serum -1.04 95% CI 1.71 to -0.38. In studies in which selenium concentrations were measured in serum, a significant correlation was observed between selenium concentration and breast cancer. In contrast, in studies in which selenium concentration was measured in toenails, the correlation was not significant. Therefore, the selenium concentration can be used as one predictor for breast cancer.

Item Type: Article
Keywords: Selenium Concentration Breast cancer Meta-analysis toenail selenium women serum risk prevention survival tissue blood mortality Biochemistry & Molecular Biology Endocrinology & Metabolism
Page Range: pp. 1-7
Journal or Publication Title: Biological Trace Element Research
Journal Index: ISI
Volume: 159
Number: 1-3
Identification Number:
ISSN: 0163-4984
Depositing User: مهندس مهدی شریفی

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