Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Congenital Hypothyroidism Screening Program in Iran; a Systematic Review and Metaanalysis

Thu Jul 25 19:31:20 2024

(2014) Congenital Hypothyroidism Screening Program in Iran; a Systematic Review and Metaanalysis. Iranian Journal of Pediatrics. pp. 665-672. ISSN 2008-2142

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Objective: Unrecognized congenital hypothyroidism (CH) leads to mental retardation. Newborn screening and thyroid therapy started within 2 weeks of age can normalize cognitive development. In this systematic review, the local results of the national CH screening program in different provinces in Iran are reviewed and evaluated. Methods: Literature on the CH screening, the national databases including SID, Medlib, Iran Medex, Magiran as well as international databases including PubMed/Medline, ISI Web of Knowledge and web of science, EMBASE, SCOPUS and Google Scholar. Appraisal was guided by a checklist assessing clarity of aims and research questions. The 95 confidence intervals were calculated by I-square models. Meta regression was introduced to explore the heterogeneity between studies. Findings: We identified 25 samples including 1425124 neonates in our country. Data were Meta analyzed using random-effects models, and we found a TSH levels of 19633 babies in the first sampling were greater than the cut-off level (TSH >= 5mIU/L). The pooled recall rate was 0.014 (95 CI: 0.013 - 0.015). According to Meta analysis the overall incidence of CH was 2/1000 (95 CI:.002 - .002). The incidence of CH did not appear to be increasing over time (P = 0.08). Conclusion: Considering TSH >= 5mIU/L as a cut-off point for recalling neonates and low positive predictive value (14) of this point shows that more investigation and research is needed for establishing accurate level of TSH as a criterion for recalling patients.

Item Type: Article
Keywords: Congenital Hypothyroidism Hypothyroidism Congenital Meta Regression Iran prevalence permanent isfahan Pediatrics
Page Range: pp. 665-672
Journal or Publication Title: Iranian Journal of Pediatrics
Journal Index: ISI
Volume: 24
Number: 6
ISSN: 2008-2142
Depositing User: مهندس مهدی شریفی

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