Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology

Sun May 26 12:10:01 2024

(2015) Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology. Current Issues in Molecular Biology. pp. 11-21. ISSN 1467-3037

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Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains. Globally, ESBLs are considered to be problematic, particularly in hospitalized patients. There is an increasing frequency of ESBL in different parts of the world. The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients. Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence.

Item Type: Article
Sadeghifard, N.UNSPECIFIED
Keywords: urinary-tract-infections gram-negative bacteria intensive-care units klebsiella-pneumoniae escherichia-coli ctx-m broad-spectrum risk-factors antibiotic-resistance antimicrobial resistance Biochemistry & Molecular Biology
Page Range: pp. 11-21
Journal or Publication Title: Current Issues in Molecular Biology
Journal Index: ISI
Volume: 17
ISSN: 1467-3037
Depositing User: مهندس مهدی شریفی

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