Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Healing Effect of Scrophularia Striata on Experimental Burn Wounds Infected to Pseudomonas Aeruginosa in Rat

Tue Jul 23 03:40:58 2024

(2015) The Healing Effect of Scrophularia Striata on Experimental Burn Wounds Infected to Pseudomonas Aeruginosa in Rat. World Journal of Plastic Surgery. pp. 16-22. ISSN 2228-7914

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BACKGROUND The cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. Recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. This study aims to investigate the medicinal effect of the ethanolic extract of Scrophularia striata on burn wound infection in in-vivo and in-vitro in comparison with silver sulfadiazine (SSD). METHODS One hundred and fifty male Sprague Dawley rats were divided into 3 equal groups. A hot plate of 1x1cm was used to create second degree burn wounds. The ethanolic extract of S. striata was provided through percolation method. Group 1 was treated with SSD, group 2 with S. striata, and group 3 was considered as control group. All animals were infected to Pseudomonas aeruginosa. On days 3, 7, 10, 14, and 21 after burn wound injury, the animals were euthanized and were evaluated histologically. The MIC and MBC were determined using the micro dilution method. RESULTS The rate of wound healing was significantly greater in S. striata group in comparison to SSD and control groups. CONCLUSION S. striata contains was shown to have anti-bacterial and wound healing effects while this effect was significantly more than SSD denoting to its use when needed for burn wounds infected to P. aeruginosa.

Item Type: Article
Rokni-Hosseini, M. H.UNSPECIFIED
Hossienzadeh, M.UNSPECIFIED
Koohi-Hossienabadi, O.UNSPECIFIED
Keywords: Scrophularia striata Wound Healing Silver sulfadiazine Pseudomonas aeruginosa Surgery
Page Range: pp. 16-22
Journal or Publication Title: World Journal of Plastic Surgery
Journal Index: ISI
Volume: 4
Number: 1
ISSN: 2228-7914
Depositing User: مهندس مهدی شریفی

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