Abstract

Vaginal Candidiasis is the most common and important opportunistic fungal infection in women By increasing use of antifungal drugs in recent years, it has caused drug resistance. This study aims to evaluate antifungal drugs susceptibility of Candida. spp isolated of women with vaginitis from Ilam-Iran during 2013-2014. samples were collected and cultured from 385 women with vaginitis, then Candidaspp was diagnosed by standard method. Antifungal drug susceptibility test for nystatin 100 unit/disk, fluconazole 10 mu g/disk, itraconazole 10 mu g/disk, ketoconazole 10 mu g/disk, amphotericinB 20 mu g/disk, clotrimazole 10 mu g/disk, posaconazole 5 mu g/disk, and voriconazole 1 mu g/disk were carried out by M44-A method(CLSI). From all culture positive samples, 150 isolates were Candida albicans and 89 isolates were non-albicans. The resistance to fluconazole, itraconazole, ketoconazole, clotrimazole, voriconazole, posaconazole, nystatin and amphotericin B was 76, 62, 72, 55, 6, 7, 1 and 0. The highest resistance was seen for fluconazole , itraconazole, and the highest susceptible was seen for nystatin and amphotericin B. These results indicate nystatin and amphotericin B can be used as the first line for empirical therapy of vaginal candidiasis in the district.