Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association Between Toxin-Antitoxin Systems and Biofilm Formation

Sat Jun 25 08:46:56 2022

(2015) Association Between Toxin-Antitoxin Systems and Biofilm Formation. Jundishapur Journal of Microbiology. p. 6. ISSN 2008-3645

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Abstract

Background: Toxin-antitoxin (TA) systems are found on the chromosomes and plasmids of many Bacteria such as Escherichia coli. The roles of TA systems in bacteria are enigmatic. Multiple biological functions of TA systems are proposed including growth modulation, persistence, and biofilm formation. Biofilms of E. coli are cause of urinary tract infections, as well as bacteraemia. Objectives: The current study aimed to find the association between biofilm formation and toxin-antitoxin systems in clinical isolates of E. coli. Materials and Methods: A total of 150 E. coli isolates were evaluated for biofilm formation by Congo red agar medium (CRA) and microtiter plate assay and the presence of different TA systems including MazEF, RelBE, hipBA, ccdAB and MqsRA. Results: The results of the analysis revealed that 107 E. coli isolates were potent for biofilm formation by CRA. The findings by microtiter plates showed that 102 E. coli isolates were biofilm producers. The results indicated that 80, 85, 70, 91 and 82 of the isolates possessed MazEF, RelBE, hipBA, ccdAB and MqsRA TA loci, respectively. Conclusions: The analysis recommended that TA genes are prevalent in clinical isolates of E. coli strains. The analysis revealed that hipBA TA system is associated with biofilm formation.

Item Type: Article
Creators:
CreatorsEmail
Karimi, S.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Kalani, M. T.UNSPECIFIED
Jalilian, F. A.UNSPECIFIED
Hemati, S.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: Biofilm Escherichia coli Toxin-Antitoxin Systems escherichia-coli multidrug tolerance resistant translation mechanisms inhibitor multiple stress mazef locus Microbiology
Divisions:
Page Range: p. 6
Journal or Publication Title: Jundishapur Journal of Microbiology
Journal Index: ISI
Volume: 8
Number: 1
Identification Number: https://doi.org/10.5812/jjm.14540
ISSN: 2008-3645
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/607

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