Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glibenclamide consumption on type 2 Diabetic rodents

Mon Oct 3 01:19:09 2022

(2015) Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glibenclamide consumption on type 2 Diabetic rodents. Food & Nutrition Research. p. 9. ISSN 1654-6628

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Background/objective: The purpose of the present study was to evaluate the effect of fenugreek seed extract in combination with swimming exercise compared to glibenclamide consumption on type 2 diabetic rats. Design: The acute toxicity test was carried out to choose the safe doses and identify the toxicity effects of the fenugreek seed extract. To investigate the hypoglycemic effect of the extract and its effect in combination with swimming training, 80 Wistar Kyoto male streptozotocin-induced diabetic rats were divided randomly into eight groups: diabetic control (C); fenugreek seed extract 0.8 g/kg (F1); fenugreek extract 1.6 g/kg (F2); swimming training (S); swimming training plus fenugreek extract 0.8 g/kg (SF1); swimming training plus fenugreek extract 1.6 g/kg (SF2); glibenclamide (G) and swimming training plus glibenclamide (SG). The rats were orally administrated with the treatments once a day with the respective treatment, and the training groups were subjected to swimming training every day for 60 min. Fasting blood samples were collected to measure fasting blood glucose, lipid profile, adiponectin, leptin, and insulin concentrations. Results: The results obtained from acute toxicity study showed no toxicity effect of fenugreek seed extract on the tested dose. Biochemical analysis showed significant improvements in all of the groups compared to the control group (p < 0.05). Plasma insulin concentration and insulin resistance (HOMA-IR) was significantly reduced in treated groups compared with the diabetic control group. Plasma leptin were significantly decreased in treated groups compared with the control group; while adiponectin had markedly increased (p < 0.05). Conclusion: The findings suggest that fenugreek seed consuming, alongside swimming exercise, has a strong therapeutic effect on the improvement of diabetic parameters.

Item Type: Article
Creators:
CreatorsEmail
Arshadi, S.UNSPECIFIED
Azarbayjani, M. A.UNSPECIFIED
Hajiaghaalipour, F.UNSPECIFIED
Yusof, A.UNSPECIFIED
Peeri, M.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Stannard, R. S.UNSPECIFIED
Abu Osman, N. A.UNSPECIFIED
Dehghan, F.UNSPECIFIED
Keywords: swimming training fenugreek seed glibenclamide lipid profile diabetic leptin insulin resistance resistance training improves fenugreek seed powder insulin-resistance adipose-tissue serum leptin glycemic control skeletal-muscle lipid profile glucose mellitus Food Science & Technology Nutrition & Dietetics
Divisions:
Page Range: p. 9
Journal or Publication Title: Food & Nutrition Research
Journal Index: ISI
Volume: 59
Identification Number: https://doi.org/10.3402/fnr.v59.29717
ISSN: 1654-6628
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/603

Actions (login required)

View Item View Item