Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model

Sat Jun 25 08:48:08 2022

(2015) Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model. Korean Journal of Pain. pp. 96-104. ISSN 2005-9159

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Abstract

Background: The present experiment was conducted to identify the cooperative effect of serine histogranin (SHG) and noradrenaline in alleviating peripheral neuropathic pain. Methods: Chronic constriction injury of the right sciatic nerve was used to induce chronic neuropathic pain. For drug delivery, a PE10 tube was inserted into the subarachnoid space. Acetone drops and a 44(o)C water bath were used to evaluate the cold and heat allodynia, respectively. Placing and grasping reflexes were used to assess the locomotor system. Results: SHG at 0.5 and 1 mu g significantly (P < 0.05) decreased the thermal allodynia. The cold allodynia was also significantly reduced by intrathecal injections of 0.5 (P < 0.05) and 1 mu g (P < 0.001) of SHG. 1 mu g of noradrenaline, but not 0.5 mu g, significantly alleviated the cold (P < 0.01) and thermal (P < 0.05) allodynia. The ameliorating effect of noradrenaline or SHG disappeared when the two compounds were administrated in equal concentrations. A significant difference (P < 0.01 in the acetone and P < 0.05 in the heat) was observed in the groups under equal doses of the two compounds, with a lower effectiveness of the combination therapy. Conclusions: Our findings suggest that the simultaneous administrations of noradrenaline and SHG do not result in synergistic analgesia, and combination therapy may not be a good approach to the treatment of chronic neuropathic pain syndrome.

Item Type: Article
Creators:
CreatorsEmail
Nasirinezhad, F.UNSPECIFIED
Hosseini, M.UNSPECIFIED
Salari, S.UNSPECIFIED
Keywords: Antagonists and Inhibitors Neuropathic pain Noradrenaline N-Methyl D-Aspartate Receptors Neurosciences & Neurology
Divisions:
Page Range: pp. 96-104
Journal or Publication Title: Korean Journal of Pain
Journal Index: ISI
Volume: 28
Number: 2
Identification Number: https://doi.org/10.3344/kjp.2015.28.2.96
ISSN: 2005-9159
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/590

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