Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

BERBERIS VULGARIS FRUIT CRUDE EXTRACT AS A NOVEL ANTI-LEUKAEMIC AGENT

Sat Jun 25 08:54:59 2022

(2015) BERBERIS VULGARIS FRUIT CRUDE EXTRACT AS A NOVEL ANTI-LEUKAEMIC AGENT. Journal of Biological Regulators and Homeostatic Agents. pp. 395-399. ISSN 0393-974X

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Abstract

Tumor protein p53 encoded by the TP53 gene in humans is known as a cancer biomarker in patients diagnosed with cancer, and it plays an essential role in apoptosis, genomic stability, and inhibition of angiogenesis. Cancer therapies with common chemotherapy methods are effective, as known, but have some side effects. Berberis vulgaris is traditionally administrated as a cancer drug. The current research aims to evaluate p53 as a biomarker in WEHI-3 cell line and to demonstrate the Berberis vulgaris fruit crude extract (BVFCE) as a new anticancer drug. For this purpose, we evaluated the effect of BVFCE in different concentrations against WEHI-3cell line in vitro and determined the quantitative level of p53 gene in the treated WEHI-3 cells. The results demonstrated that even at only 1 mg/ml concentration of Berberis vulgaris crude extract, there was a low level of p53 biomarker expression on WEHI-3 cells in comparison with doxorubicin. Therefore, the current study suggests BVFCE as a reliable anti-leukaemic drug and candidate for anticancer therapy. However, further investigation need be carried out to confirm its efficiency in vivo.

Item Type: Article
Creators:
CreatorsEmail
Saedi, T. A.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Jafarlou, M.UNSPECIFIED
Sabariah, M. N.UNSPECIFIED
Ismail, P.UNSPECIFIED
Eusni, R. M. T.UNSPECIFIED
Othman, F.UNSPECIFIED
Keywords: BVFCE anti-leukaemia WEHI-3 qRT-PCR p53 breast-cancer p53 expression in-vitro prognosis Endocrinology & Metabolism Immunology Research & Experimental Medicine Physiology
Divisions:
Page Range: pp. 395-399
Journal or Publication Title: Journal of Biological Regulators and Homeostatic Agents
Journal Index: ISI
Volume: 29
Number: 2
ISSN: 0393-974X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/584

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