Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE

Sat Jun 25 03:45:21 2022

(2015) MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE. Journal of Biological Regulators and Homeostatic Agents. pp. 327-334. ISSN 0393-974X

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Abstract

Pulmonary fibrosis occurs as a common end-stage sequela of a number of acute and chronic lung diseases. Eicosanoids exert crucial roles in inflammatory processes pertinent to fibrogenesis induction, however, the role of cyclooxygenase 2 (COX-2) is not fully elucidated in most pulmonary fibrosis related-disorders. Recently, melatonin (MLN) has been introduced as an effective immuno-modulator and anti-oxidant agent. The present study aimed to investigate the effect of MLN on COX-2 expression in idiopathic pulmonary fibrosis (IPF). Animals were divided into five groups, including: 1) saline control, 2) 1 ethanol control, 3) MLN control, 4) bleomycin (BLM), in which mice were injected with BLM (15 mg/kg, i.p.) two times per week for four weeks, and 5) BLM+MLN, in which MLN was given to mice (10 mg/kg, i.p.) 30 minutes prior to BLM injections for four weeks. MLN administration significantly reduced body weight loss (P<0.05), the rate of mortality, edema formation, lung injury, COX-2 expression (P>0.05), interstitial tissue percentage volume (P<0.05), and also increased the alveolar space percentage volume. MLN attenuated the BLM-induced lung injury responses such as collagen accumulation and airway dysfunction in mice. Finally, histological evidence supported the ability of MLN to inhibit COX-2 expression. Thus, it may serve as a novel potential therapeutic agent for IPF.

Item Type: Article
Creators:
CreatorsEmail
Karimfar, M. H.UNSPECIFIED
Rostami, S.UNSPECIFIED
Haghani, K.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Keywords: melatonin pulmonary fibrosis cyclooxygenase 2 bleomycin cox-2 inhibition cells rat Endocrinology & Metabolism Immunology Research & Experimental Medicine Physiology
Divisions:
Page Range: pp. 327-334
Journal or Publication Title: Journal of Biological Regulators and Homeostatic Agents
Journal Index: ISI
Volume: 29
Number: 2
ISSN: 0393-974X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/583

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