Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa

Thu Dec 1 16:22:44 2022

(2015) Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa. Revista Da Sociedade Brasileira De Medicina Tropical. pp. 432-436. ISSN 0037-8682

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Introduction: Chamomile (Chamaemelum nobile) is widely used throughout the world, and has anti-inflammatory, deodorant, bacteriostatic, antimicrobial, carminative, sedative, antiseptic, anti-catarrhal, and spasmolytic properties. Because of the increasing incidence of drug-resistant bacteria, the development of natural antibacterial sources such as medical herbs for the treatment of infectious diseases is necessary. Extracts from different plant parts such as the leaves, flowers, fruit, and bark of Combretum albiflorum, Laurus nobilis, and Sonchus oleraceus were found to possess anti-quorum sensing (QS) activities. In this study, we evaluated the effect of C. nobile against Pseudomonas aeruginosa biofilm formation. Methods: The P. aeruginosa samples were isolated from patients with different types of infection, including wound infection, septicemia, and urinary tract infection. The flowers of C. nobile were dried and the extract was removed using a rotary device and then dissolved in dimethyl sulfoxide at pH 7.4. The microdilution method was used to evaluate the minimum inhibitory concentration (MIC) of this extract on P. aeruginosa, and biofilm inhibition was assayed. Results: Eighty percent of the isolated samples (16/20) could form a biofilm, and most of these were isolated from wound infections. The biofilm inhibitory concentration of the C. nobile extract was 6.25-25mg/ml, whereas the MIC was 12.5-50mg/ml. Conclusions: The anti-QS property of C. nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. However, molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound.

Item Type: Article
Creators:
CreatorsEmail
Kazemian, H.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Heidari, H.UNSPECIFIED
Amiri, P.UNSPECIFIED
Yamchi, J. K.UNSPECIFIED
Shavalipour, A.UNSPECIFIED
Houri, H.UNSPECIFIED
Maleki, A.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: Anti-quorum sensing (QS) Antibacterial Chamaemelum nobile Biofilm Pseudomonas aeruginosa quorum-sensing inhibitors gram-negative bacteria virulence factors extracts ginseng signals agents pao1 Parasitology Tropical Medicine
Divisions:
Page Range: pp. 432-436
Journal or Publication Title: Revista Da Sociedade Brasileira De Medicina Tropical
Journal Index: ISI
Volume: 48
Number: 4
Identification Number: https://doi.org/10.1590/0037-8682-0065-2015
ISSN: 0037-8682
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/566

Actions (login required)

View Item View Item