Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H-pylori infection

Mon Oct 3 01:05:27 2022

(2015) Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H-pylori infection. Journal of Clinical Pharmacology. pp. 842-847. ISSN 0091-2700

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Abstract

Chronic gastritis associated with H. pylori infection causes oxidative stress in the stomach. This study aimed to evaluate the therapeutic effects of coenzyme q10 among gastric patients infected by H. pylori. By a clinical trial, chronic gastric patients infected by H. pylori were randomly divided into 2 groups: intervention and placebo. The placebo group received a standard triple therapy regimen, and the intervention group received the triple regimen+coenzyme Q10 (CoQ10). Mean inflammation score; serum levels of 3 serum markers were then compared. A total of 100 participants of whom 67 were female were evaluated. The mean age of participants was 59.4 +/- 11.4 years. The mean inflammation score was considerably decreased at the end of the study, in the intervention group. The mean levels of total antioxidant capacity (TAC) and glutathione peroxidase (GPx) at the end of the study were reduced among the triple therapy group (P<.05, P=.03 respectively). The mean levels of TAC and GPx were significantly higher among the intervention group at the end of the study compared with those at the start of the study. The combination of triple therapy with CoQ10 demonstrated an effective outcome on the mucosal inflammation, and stress oxidative in patients with chronic gastritis.

Item Type: Article
Creators:
CreatorsEmail
Rahmani, A.UNSPECIFIED
Abangah, G.UNSPECIFIED
Moradkhani, A.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: chronic gastritis H pylori coenzyme Q10 (CoQ10) total antioxidant capacity (TAC) glutathione peroxidase (GPx) malondialdehyde (MDA) inflammation cancer indomethacin antioxidants deficiency disease risk Pharmacology & Pharmacy
Divisions:
Page Range: pp. 842-847
Journal or Publication Title: Journal of Clinical Pharmacology
Journal Index: ISI
Volume: 55
Number: 8
Identification Number: https://doi.org/10.1002/jcph.508
ISSN: 0091-2700
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/560

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